The impact of relative humidity during electrospinning on the morphology and mechanical properties of nanofibers

Pelipenko, Jan; Kristl, Julijana; Janković, Biljana; Baumgartner, Stephan; Kocbek, Petra

doi:10.1016/j.ijpharm.2013.07.078

Cited by 252 publications

(191 citation statements)

References 34 publications

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“…Compared with F1, the bead was seen in the F3 formulation at a voltage of 20 kV. The voltage could be increased, but only up to a certain limit; if increased further after this point, this led to ragged and incomplete fiber formation, as the electrostatic repulsive force on fibers was too high (19,20).…”

Section: Resultsmentioning

confidence: 98%

The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

Akhgari

Dezfuli

Rezaei

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Due to their optimal mechanical and biological properties, nanofibers have numerous medical applications. Electrospinning is one of the widely used techniques for generating drug-containing nanofibers. Objectives: The aim of this study was to assess the use of the electrospinning method to prepare fast-dissolving loratadine nanofibers. Materials and Methods: Polyvinylpyrrolidone (PVP) nanofibers containing loratadine were produced using the electrospinning method. A full factorial design was employed to evaluate the formulations, including the four following variables: the concentration of PVP, the ratio of drug to polymer, the feed rate, and the voltage applied at two levels. After preparing the samples, assessments were carried out using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). Dissolution tests and determination of the time of disappearance were also carried out. It was observed that reducing the concentration of polymer, reducing the feed rate, and increasing the voltage applied to the polymeric solution up to an adequate amount allowed the possibility of creating nanofibers with a smaller diameter and greater uniformity. Results:The results showed that the fiber diameter and the amount of loratadine affected the drug release and the disappearance time of nanofibers. The smaller the fiber diameter and drug amount, the faster the solubility and the release time of nanofibers. Conclusions: It was concluded that electrospinning can be a suitable method for preparing fast-dissolving loratadine nanofibers.

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Section: Resultsmentioning

confidence: 98%

The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

Akhgari

Dezfuli

Rezaei

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Some electrospinning conditions, such as the air humidity also have an impact on the mechanical properties of the mats [26]. The architecture of the micro-and nanoscale fibrous materials is of importance, as well: when they are composed of oriented fibers the mat is stronger compared to mats composed of randomly deposited fibers [27,28].…”

Section: Mechanical Testing Of the Fibrous Materialsmentioning

confidence: 99%

Enhancing the mechanical properties of electrospun polyester mats by heat treatment

Kancheva¹,

Toncheva²,

Manolova³

et al. 2015

Express Polym. Lett.

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Abstract. Microfibrous materials with a targeted design based on poly(L-lactic acid) (PLA) and poly(!-caprolactone) (PCL) were prepared by electrospinning and by combining electrospinning and electrospraying. Several approaches were used: (i) electrospinning of a common solution of the two polymers, (ii) simultaneous electrospinning of two separate solutions of PLA and PCL, (iii) electrospinning of PLA solution in conjunction with electrospraying of PCL solution, and (iv) alternating layer-by-layer deposition by electrospinning of separate PLA and PCL solutions. The mats were heated at the melting temperature of PCL (60°"), thus achieving melting of PCL fibers/particles and thermal sealing of the fibers. The mats subjected to thermal treatment were characterized by greater mean fiber diameters and reduced values of the water contact angle compared to the pristine mats. Heat treatment of the mats affected their thermal stability and led to an increase in the crystallinity degree of PLA incorporated in the mats, whereas that of PCL was reduced. All mats were characterized by enhanced mechanical properties after thermal treatment as compared to the non-treated fibrous materials.

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“…It was reported that, the evaporation rate of solvent as an important factor to control the terminal fiber diameter [25]. Here, introduction of hydrophobic methacryloyl groups reduced hydrophilicity of PVA, and thus more water molecules were not bonded closely with -OH of PVA with DS increased, leading to rapid increase of the rate of water evaporation during electrospinning, which consequentially also caused a rapid increase of polymer viscosity, which reduced the voltage induced stretching of polymer chain, resulting in the formation of wider fibers [26]. In other words, MPVA jet solidified sooner after it came out of the needle, and therefore exposed to voltage induced stretching for a shorter time only, leading to formation of wider fibers, with DS increased.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds

Chen

Liu²,

Dong

et al. 2016

J. Photopol. Sci. Technol.

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Biocompatible photocrosslinked poly(vinyl alcohol) nanofibrous Scaffolds were successfully prepared by electrospinning and consequent photopolymerization. The nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). SEM images showed that morphology and diameter of the nanofibers were mainly affected by degree of substitute of metharyloyl group. XRD and DSC demonstrated form of a larger fraction of amorphous phase due to destroyed hydrogen bonding through methacrylation. Water stability test showed that the nanofibrous membranes improved its water stability with crosslinking degree increased. The indirect cytotoxicity assessments of the nanofibers were studied. And the result indicated the nanofibers was nontoxic to the L929 cells. This novel electrospun matrix would be used as potential wound dressing for skin regeneration.

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The impact of relative humidity during electrospinning on the morphology and mechanical properties of nanofibers

Cited by 252 publications

References 34 publications

The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

Enhancing the mechanical properties of electrospun polyester mats by heat treatment

Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds

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