The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females

McGarity-Shipley, Ellen C; Schmitter, Sarah; Williams, Jennifer S.; King, Trevor J.; McPhee, Iain; Pyke, Kyra E.

doi:10.1007/s00421-021-04749-7

Cited by 5 publications

(3 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…after repeated bouts of heat exposure, although these are not universal findings (Akerman et al, 2019;McGarity-Shipley et al, 2021). To gain a better understanding of how heat exposure might modulate vascular function, studies have also considered the acute effect of heat exposure on FMD and/or PORH.…”

Section: Introductionmentioning

confidence: 99%

“…This interest is attributable, in part, to the effect of heat exposure on macro‐ and microvascular function, measured by flow‐mediated dilatation (FMD) and vascular conductance during postocclusion reactive hyperaemia (PORH), respectively. In some interventional studies, improvements in FMD (Bailey et al., 2016 ; Brunt, Howard et al., 2016 ; Imamura et al., 2001 ; Kihara et al., 2002 ; Naylor et al., 2011 ) or PORH (Brunt, Howard et al., 2016 ) have been observed after repeated bouts of heat exposure, although these are not universal findings (Akerman et al., 2019 ; McGarity‐Shipley et al., 2021 ). To gain a better understanding of how heat exposure might modulate vascular function, studies have also considered the acute effect of heat exposure on FMD and/or PORH.…”

Section: Introductionmentioning

confidence: 99%

“…Third, it remains unknown whether biological sex contributes to the variable effect of acute heat exposure on vascular function, because previous studies have reported results from males only (Alali et al., 2020 ; Cheng et al., 2019 ; Coombs et al., 2019 ; Tinken et al., 2009 ), combined groups of males and females (Behzadi et al., 2022 ; Brunt, Jeckell et al., 2016 ; Cheng et al., 2021 ; Engelland et al., 2020 ; Gravel et al., 2020 , 2019 ; Romero et al., 2017 ; Thomas et al., 2016 ) or studied females only (McGarity‐Shipley et al., 2021 ). It is possible that biological sex modulates the acute effect of heat exposure on vascular function, because females display greater increases in shear stress and/or core temperature for a given heating stimulus (Larson et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Chaseling

Debray

Gravel

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

New Findings What is the central question of this study?Do measurement timing, heating modality and biological sex modulate the acute effect of heat exposure on brachial artery flow‐mediated dilatation and postocclusion reactive hyperaemia? What is the main finding and its importance?The acute effect of heat exposure on brachial artery flow‐mediated dilatation and postocclusion reactive hyperaemia is: (1) transient and short lasting; (2) different between forearm and whole‐body heating; (3) unaffected by forearm heating during whole‐body heating; and (4) not different but not always equivalent between males and females. These findings provide a useful basis for future studies to investigate the acute effect of heat exposure on vascular function. Abstract The aim of this study was to gain a better understanding of the acute effect of heat exposure on brachial artery flow‐mediated dilatation (FMD) and postocclusion reactive hyperaemia (PORH) by: characterizing the time course of changes post‐heating; comparing forearm and whole‐body heating; determining the impact of forearm heating during whole‐body heating; and comparing males and females. Twenty adults (11 males and nine females; 28 ± 6 years of age) underwent two forearm [10 min electric blanket (EB) or 30 min hot water immersion (WI)] and two whole‐body [60 min water‐perfused suit with forearm covered (WBH‐C) or uncovered (WBH‐U)] heating modalities. The FMD and PORH were measured before and after (≤5, 30, 60, 90 and 120 min) heating. The FMD increased from baseline 30 min after EB, and 30 and 90 min after WI. In contrast, FMD decreased from baseline immediately after both WBH modalities. Peak PORH increased immediately after WI and both WBH modalities. Total PORH did not differ after WI, whereas it decreased immediately after both WBH modalities. Covering the forearm during WBH did not alter acute changes in FMD or PORH. Changes in FMD and PORH did not differ statistically between males and females during each heating modality, although the observed differences could not always be considered equivalent. These results demonstrate that the acute effect of heat exposure on brachial artery FMD and PORH is: (1) transient and short lasting; (2) different between forearm heating and WBH; (3) unaffected by direct forearm heating during WBH; and (4) not different but not always equivalent between males and females.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Chaseling

Debray

Gravel

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

show abstract

Endothelial HSP72 is not reduced in type 2 diabetes nor is it a key determinant of endothelial insulin sensitivity

Pettit‐Mee

Power

Cabral-Amador

et al. 2022

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Impaired endothelial insulin signaling and consequent blunting of insulin-induced vasodilation is a feature of type 2 diabetes (T2D) that contributes to vascular disease and glycemic dysregulation. However, the molecular mechanisms underlying endothelial insulin resistance remain poorly known. Herein, we tested the hypothesis that endothelial insulin resistance in T2D is attributed to reduced expression of heat shock protein 72(HSP72). HSP72 is a cytoprotective chaperone protein that can be upregulated with heating and is reported to promote insulin sensitivity in metabolically active tissues, in part via inhibition of JNK activity. Accordingly, we further hypothesized that, in T2D individuals, seven days of passive heat treatment via hot water immersion to waist-level would improve leg blood flow responses to an oral glucose load (i.e., endogenous insulin stimulation) via induction of endothelial HSP72. In contrast, we found that: 1) endothelial insulin resistance in T2D mice and humans was not associated with reduced HSP72 in aortas and venous endothelial cells, respectively; 2) after passive heat treatment, improved leg blood flow responses to an oral glucose load did not parallel with increased endothelial HSP72; 3) downregulation of HSP72 (via small-interfering RNA) or upregulation of HSP72 (via heating) in cultured endothelial cells did not impair or enhance insulin signaling, respectively, nor was JNK activity altered. Collectively, these findings do not support the hypothesis that reduced HSP72 is a key driver of endothelial insulin resistance in T2D but provide novel evidence that lower-body heating may be an effective strategy for improving leg blood flow responses to glucose ingestion-induced hyperinsulinemia.

show abstract

Effects of home-based leg heat therapy on walking performance in patients with symptomatic peripheral artery disease: a pilot randomized trial

Monroe

Pae

Kargl

et al. 2022

Journal of Applied Physiology

View full text Add to dashboard Cite

Few non-invasive therapies currently exist to improve functional capacity in people with lower extremity peripheral artery disease (PAD). The goal of the present study was to test the hypothesis that unsupervised, home-based leg heat therapy (HT) using water-circulating trousers perfused with warm water would improve walking performance in patients with PAD. Symptomatic PAD patients were randomized into either leg HT (n=18) or a sham treatment (n=16). Patients were provided with water-circulating trousers and a portable pump and were asked to apply the therapy daily (7 days/week, 90 min per session) for 8 weeks. The primary study outcome was the change from baseline in 6-minute walk distance at 8-week follow-up. Secondary outcomes included the claudication onset-time, peak walking time, peak pulmonary oxygen consumption and peak blood pressure during a graded treadmill test, resting blood pressure, the ankle-brachial index, post-occlusive reactive hyperemia in the calf, cutaneous microvascular reactivity and perceived quality of life. Of the 34 participants randomized, 29 completed the 8-week follow-up. The change in 6-minute walk distance at the 8-week follow-up was significantly higher (p=0.029) in the group exposed to HT as compared to the sham-treated group (Sham: median: -0.9; 25%,75% percentiles: -5.8,14.3; HT: median: 21.3; 25%,75% percentiles: 10.1,42.4, p=0.029). There were no significant differences in secondary outcomes between the HT and sham group at 8-week follow-up. The results of this pilot study indicate that unsupervised, home-based leg HT is safe, well-tolerated and elicits a clinically meaningful improvement in walking tolerance in patients with symptomatic PAD.

show abstract

The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females

Cited by 5 publications

References 68 publications

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Endothelial HSP72 is not reduced in type 2 diabetes nor is it a key determinant of endothelial insulin sensitivity

Effects of home-based leg heat therapy on walking performance in patients with symptomatic peripheral artery disease: a pilot randomized trial

Contact Info

Product

Resources

About