On the basis of the construction of urbanization and ecology index system, this study takes the core area of Silk Road Economic Belt, Gansu, as the research object and creates the coordination evaluation model between urbanization and ecological environment in Gansu; meanwhile, it uses BP neural network to predict the coordinated development of urbanization and ecology in Gansu Province. Finally, the aforesaid model is validated by means of empirical evidence. The results show that Gansu, in the Silk Road Economic Belt, has accelerated its urbanization level in the 10-year period from 2010 to 2019 in the context of the Belt and Road Initiative, especially in Jiayuguan and Lanzhou, mainly due to its industrialization-led urbanization; meanwhile, in terms of coupling degree, most of them are between 0.45 and 0.55, and most of them are out-of-frequency pro-disorder recession type, indicating that under the background of urbanization, the ecology of each city and prefecture in Gansu is also under great pressure. At the same time, through the forecast, Gansu is considered to be in the red light in 2019, as the endangered disorder recession B environmental lagging type, indicating that Lanzhou is facing great ecological pressure, but in general, the relationship between human and land is gradually developing in harmony.