The Impact of Vitamin D on Skin Aging

Bocheva, Georgeta; Slominski, Radomir M.; Słomiński, Andrzej

doi:10.3390/ijms22169097

Cited by 75 publications

(61 citation statements)

References 236 publications

(339 reference statements)

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“…Aging is associated with a decline in circadian rhythm and a dampening of circadian gene expression [30] that can augment oxidative stress through an increased generation and accumulation of reactive oxygen species (ROS) [31]. Melatonin as well as vitamin D can regulate the cutaneous redox state and circadian rhythm [17,32].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva

Slominski

Janjetovic

et al. 2022

IJMS

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The skin, being the largest organ in the human body, is exposed to the environment and suffers from both intrinsic and extrinsic aging factors. The skin aging process is characterized by several clinical features such as wrinkling, loss of elasticity, and rough-textured appearance. This complex process is accompanied with phenotypic and functional changes in cutaneous and immune cells, as well as structural and functional disturbances in extracellular matrix components such as collagens and elastin. Because skin health is considered one of the principal factors representing overall “well-being” and the perception of “health” in humans, several anti-aging strategies have recently been developed. Thus, while the fundamental mechanisms regarding skin aging are known, new substances should be considered for introduction into dermatological treatments. Herein, we describe melatonin and its metabolites as potential “aging neutralizers”. Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. It regulates circadian rhythmicity and also exerts anti-oxidative, anti-inflammatory, immunomodulatory, and anti-tumor capacities. The intention of this review is to summarize changes within skin aging, research advances on the molecular mechanisms leading to these changes, and the impact of the melatoninergic anti-oxidative system controlled by melatonin and its metabolites, targeting the prevention or reversal of skin aging.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva

Slominski

Janjetovic

et al. 2022

IJMS

Self Cite

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“…VD3 has implicated in bone metabolism, but recently it has been identified as a potential contributor to the extraosseous pathophysiological conditions in many tissues and organs, including brain [17,24,25], kidney [26], immune system [27], skin [28], and others. Our previous results showed accelerated wound repair with VD3 but without complete repair [8].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D3 and Silver Nanoparticles on HaCaT Cell Viability

Cataldi

Ceccarini

Patria

et al. 2022

IJMS

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Vitamin D3, known to regulate bone homeostasis, has recently been shown to have many pleiotropic effects in different tissues and organs due to the presence of its receptor in a wide range of cells. Our previous study demonstrated that vitamin D3 was able to increase the wound healing respect to the control sample, 24 h after cutting, without however leading to a complete repair. The aim of the study was to combine vitamin D3 with silver nanoparticles to possibly enable a faster reparative effect. The results showed that this association was capable of inducing a complete wound healing only after 18 h. Moreover, a treatment of vitamin D3 + silver nanoparticles yielded a small percentage of keratinocytes vimentin-positive, suggesting the possibility that the treatment was responsible for epithelial to mesenchymal transition of the cells, facilitating wound healing repair. Since vitamin D3 acts via sphingolipid metabolism, we studied the expression of gene encoding for the metabolic enzymes and protein level. We found an increase in neutral sphingomyelinase without involvement of neutral ceramidase or sphingosine kinase2. In support, an increase in ceramide level was identified by Ultrafast Liquid Chromatography–Tandem Mass Spectrometry, suggesting a possible involvement of ceramides in wound healing process.

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“…Sun exposure, as well as PUVA or NB-UVB, is a widely accepted form of treatment of psoriasis. However, potentially important adverse effects of “light therapy”, including skin aging [ 129 ] and skin cancer [ 130 ], should be carefully considered. On the other hand, seasonal lack of sunlight observed at higher latitudes (e.g., Northern Europe) is believed to be the main factor in the development of depression [ 131 ].…”

Section: Sunlight Deficiency Influences Psoriasis and Depressionmentioning

confidence: 99%

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

Marek-Józefowicz

Czajkowski

Borkowska

et al. 2022

IJMS

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Psoriasis is a chronic inflammatory skin disease with systemic manifestation, in which psychological factors play an important role. The etiology of psoriasis is complex and multifactorial, including genetic background and environmental factors such as emotional or physical stress. Psychological stress may also play a role in exacerbation of psoriasis, by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic–adrenal–medullary axis, peripheral nervous system, and immune system. Skin cells also express various neuropeptides and hormones in response to stress, including the fully functional analog of the HPA axis. The deterioration of psoriatic lesions is accompanied by increased production of inflammatory mediators, which could contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. Therefore, deregulation of the crosstalk between endocrine, paracrine, and autocrine stress signaling pathways contributes to clinical manifestations of psoriasis, which requires multidisciplinary approaches.

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The Impact of Vitamin D on Skin Aging

Cited by 75 publications

References 236 publications

Protective Role of Melatonin and Its Metabolites in Skin Aging

Protective Role of Melatonin and Its Metabolites in Skin Aging

The Effect of Vitamin D3 and Silver Nanoparticles on HaCaT Cell Viability

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

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