The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers

Khalifa, Olla A.; Wakeel, Rasha A. Al; Hemeda, Shabaan A.; Abdel-Daim, Mohamed M.; Albadrani, Ghadeer M.; Askary, Ahmad El; Fadl, Sabreen E.; Elgendey, Fatma

doi:10.1186/s12917-021-02963-1

Cited by 23 publications

(18 citation statements)

References 33 publications

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“…In this study, the antibody titer against the NDV showed a nonsignificant difference between the control and treated groups. Similarly, in Abed and Ezzat (2021) and Khalifa et al (2021), no significant differences among different groups given nano-and ZnO NPs for NDV disease were found (P ≤ 0.05). In contrast, the authors in Khajarern et al (2002) have indicated that high levels of Zn supplementation (75 vs. 175 mg/kg) have led to a high antibody titer for NDV disease and IB.…”

Section: Discussionmentioning

confidence: 83%

“…These lesions could be attributed to oxidative stress and the upregulations in gene expression of IL1α and TNF-α. This correlated increment in ROS production and inflammatory cytokines can diminish the mitochondrial function within cells (Hussain et al 2005 ; Khalifa et al 2021 ; Xia et al 2006 ), leading to moderate to severe damage in the internal morphology of different organs.…”

Section: Discussionmentioning

confidence: 99%

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Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Dosoky

Albanna

Zahran

et al. 2022

Environ Sci Pollut Res

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This research evaluates the effect of dietary zinc oxide nanoparticles’ (ZnO NPs) supplementation on growth performance, immunity, oxidative antioxidative properties, and histopathological picture of broiler chicken reared in the summer season. A total of 224 1-day-old male Cobb chicks were randomly allocated to seven groups of dietary treatments (n = 32). Seven isocaloric and isonitrogenous diets were formulated. ZnO NPs were added to the basal diet at seven different levels, 0, 5, 10, 20, 40, 60, and 80 ppm/kg diet, respectively, for 35 days. Results indicated that live body weight (g) did not differ significantly (P > 0.05) between treatment groups, whereas compared to control, the 5 ppm ZnO NPs/kg diet recorded the highest live body weight at 21 and 35 days. No significant effects for the feed consumption (g/bird/period) and feed conversion ratio (g feed/g gain) among treated and control birds were observed. Hematological and immunological variables showed significant (P ≤ 0.05) dose-dependent modulations by ZnO NP supplementation. Significant (P ≤ 0.05) differences were observed in the phagocytic activity, phagocytic index, and IgM and IgG between the treatment groups, with the 5 and 10 ppm ZnO NPs/kg diet recording the best values, followed by the 20 ppm ZnO NPs/kg diet. Different supplementations had nonsignificant effects on the digestibility of nutrients (P ≤ 0.05). Histopathological pictures of the kidney, liver, and lymphoid organs, ultrastructural examination of muscle tissues, and expression of inflammatory cytokines showed dose-dependent morphological and structural changes. In conclusion, the ZnO NP supplementation in broiler diet to eliminate the heat stress hazards in summer season is recommended in dose level of not more than 10 ppm/kg diet.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Dosoky

Albanna

Zahran

et al. 2022

Environ Sci Pollut Res

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“…Moreover, selenium is required for GPx, which transforms H 2 O 2 and lipid hydroperoxides into alcohols [ 21 , 22 ]. Vitamin E and selenium, in particular their antioxidant and immune functions, can work together to influence biological processes [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers

et al. 2022

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Background In contrast to free radicals, the first line of protection is assumed to be vitamin E and selenium. The present protocol was designed to assess the roles of vitamin E and/or a selenium-rich diet that affected the blood iron and copper concentrations, liver tissue antioxidant and lipid peroxidation, and gene expression linked to antioxidants in the liver tissue of broilers. The young birds were classified according to the dietary supplement into four groups; control, vitamin E (100 mg Vitamin/kg diet), selenium (0.3 mg sodium selenite/kg diet), and vitamin E pulse selenium (100 mg vitamin/kg diet with 0.3 mg sodium selenite/kg diet) group. Results The results of this experiment suggested that the addition of vitamin E with selenium in the broiler diet significantly increased (P ≤ 0.05) serum iron when compared with the other groups and serum copper when compared with the vitamin E group. Moreover, the supplements (vitamin E or vitamin E with selenium) positively affected the enzymatic activity of the antioxidant-related enzymes with decreased malondialdehyde (MDA),which represents lipid peroxidation in broiler liver tissue. Moreover, the two supplements significantly upregulated genes expression related to antioxidants. Conclusion Therefore, vitamin E and/or selenium can not only act as exogenous antioxidants to prevent oxidative damage by scavenging free radicals and superoxide, but also act as gene regulators, regulating the expression of endogenous antioxidant enzymes.

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“…Only a few clinical trials have been carried out to study the effect of selenium in combination with vitamin E alone. However, there is a multitude of studies on this specific combination in animals, such as rats or chickens [ 158 , 159 , 160 , 161 ].…”

Section: Nutritional Factors Interfering With the Effects Of Vitamin ...mentioning

confidence: 99%

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in broilers

Cited by 23 publications

References 33 publications

Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Zinc oxide nanoparticles induce dose-dependent toxicosis in broiler chickens reared in summer season

Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

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