The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review

Schliemann, Désirée; Ramanathan, Kogila; Matovu, Nicholas; O’Neill, Ciarán; Kee, Frank; Su, Tin Tin; Donnelly, Michael

doi:10.1186/s12885-021-08809-1

Cited by 36 publications

(42 citation statements)

References 59 publications

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“…The most common diagnostic methods for patients with CRC include colonoscopy and serum tumor marker detection [ 8 ]. Colonoscopy has a high specificity and sensitivity, allowing it to identify illnesses more precisely; yet, the expense of colonoscopy is high, putting patients under financial strain and reducing their bearing capacity.…”

Section: Introductionmentioning

confidence: 99%

Expression Levels and Clinical Significance of Serum miR-497, CEA, CA24-2, and HBsAg in Patients with Colorectal Cancer

Liu

Chen

2022

BioMed Research International

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The objective of the current study was to look at the levels of blood micro ribonucleic acid- (miR-) 497, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 24-2, and hepatitis B surface antigen (HBsAg) in patients with colorectal cancer (CRC), as well as the clinical importance of these markers in CRC patients. The serum levels of miR-497, CEA, CA24-2, and HBsAg were compared between 60 patients with CRC (observation group) and another 60 patients with colorectal polyps (control group). The 4 indicators in patients with lymph node metastasis and liver metastasis were compared. The diagnostic effects of 4 detection methods and the combined detection were analyzed, and the influence of 4 indicators on the 5-year cumulative survival rate of patients was discussed. The results showed that the serum levels of miR-497 and HBsAg were lower, and the levels of CEA and CA24-2 were higher in the observation group ( P < 0.05 ). The combined detection had the best diagnostic effect, and CEA alone had the best prediction effect. The serum level of miR-497 was significantly lower in patients with lymphatic metastasis, with the significantly higher levels of CEA and CA24-2 ( P < 0.05 ). The HBsAg level of patients with liver metastases was greatly lower than that of patients without liver metastases ( P < 0.05 ). The 5-year cumulative survival rate of patients with high levels of CEA and CA24-2 was significantly lower than that of patients with low level of CEA. The 5-year cumulative survival rate was lower in patients with low level of HBsAg, but the difference was small. The 5-year cumulative survival rate of patients with elevated serum miR-497 was observably lower. In conclusion, combined detection could diagnose CRC more accurately. Serum miR-497, CEA, and CA24-2 were important in the diagnosis of lymph node metastasis of CRC. HBsAg did a better job of predicting liver metastases in CRC patients. High level of CEA significantly reduced the cumulative survival rate of CRC patients and could predict the long-term survival rate of patients. Serum levels of miR-497, CEA, CA24-2, and HBsAg played a positive role in the diagnosis and evaluation of CRC and could identify lymph node and liver metastases, having a high clinical guidance value.

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Section: Introductionmentioning

confidence: 99%

Expression Levels and Clinical Significance of Serum miR-497, CEA, CA24-2, and HBsAg in Patients with Colorectal Cancer

Liu

Chen

2022

BioMed Research International

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“… 65–67 Notwithstanding that, the availability of treatment for CRC must be prioritized to ensure successful screening. 23 Concerted efforts by multidisciplinary teams are needed to identify the most effective strategies that suit the country’s background, considering the life-years gained relative to the cost of the screening strategy.…”

Section: Discussionmentioning

confidence: 99%

“…The health policy, capacity of the health system and public awareness are all likely to have a great impact on the uptake of CRC screening, particularly of the older age group. 23 , 25 , 28 , 30 These seem to arise as cross-cutting issues throughout the high-, middle-, and low-income countries.…”

Section: Introductionmentioning

confidence: 99%

Disparities in Recommendations for Colorectal Cancer Screening Among Average-Risk Individuals: An Ecobiosocial Approach

Soffian¹,

Nawi²,

Hod³

et al. 2022

RMHP

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Regardless of the high global burden of colorectal cancer (CRC), the uptake of CRC screening varies across countries. This systematic review aimed to provide a picture of the disparities in recommendations for CRC screening in average-risk individuals using an ecobiosocial approach. It was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The literature search was conducted through Scopus, Web of Science, PubMed, and EBSCOHost. Full-text guidelines which were published between 2011 and 2021, along with guidelines which provided recommendations on CRC screening in average-risk individuals, were included in the review. However, guidelines focusing only on a single screening modality were excluded. Fourteen guidelines fulfilling the eligibility criteria were retained for the final review and analysis. Quality assessment of each guideline was performed using the AGREE II instrument. Disparities in guidelines identified in this review were classified into ecological (screening modalities and strategies), biological (recommended age, gender and ethnicities), and social (smoking history, socioeconomic status, and behavior) factors. In general, unstandardized practices in CRC screening for average-risk individuals are likely attributable to the inconsistent and non-specific recommendations in the literature. This review calls on stakeholders and policymakers to review the existing colorectal cancer screening practices and pursue standardization.

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“…For low-income and middle-income countries, CRC screening programs should be cost-effective and culturally acceptable, healthcare infrastructure needs to be improved, and policies that can promote healthy lifestyles and reduce the involvement of high-risk factors should be developed (36,37).…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden of colorectal cancer and attributable risk factors, from 1990 to 2019: Updated results from the Global Burden of Disease Study 2019

Liu

Zhang

Wang

et al. 2022

Preprint

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Background: This study aimed to evaluate the global trends of colorectal cancer from 1990 to 2019 and the relevant risk factors for better policymaking and resource allocation.Methods: Data on CRC, including incidence, mortality, and disability adjusted life year (DALY) rates, were extracted from the 2019 Global Burden of Disease (GBD) study. The estimated annual percentage changes (EAPCs) were calculated to assess the trend of incidence, mortality, and DALYs, and the risk factor attributable deaths and DALYs were assessed based on the comparative risk assessment framework.Results: In 2019, a total of 2.166×106 CRC cases were reported worldwide, a 157% increase compared with that reported in 1990. In high-social demographic index (SDI) regions, the trend of age-standardized incidence rate has decreased, while the proportion of people younger than 50 years has increase. Although the number of deaths and DALYs increased, the age-standardized death rate and age-standardized DALY rate was decreased. The middle-SDI regions have the fastest growing CRC burden, especially in East Asia, followed by the low-SDI regions, in which the CRC burden in women has increased faster than that in man. In addition, the milk intake, High-BMI, and high fasting plasma glucose play a more important role in on CRC.Conclusion: In developed regions, the CRC burden tended to be easier, while the CRC burden became more severe in undeveloped regions. Therefore, reasonable resource allocation and prevention policies should be implemented to avoid an increase in the burden of CRC.

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The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review

Cited by 36 publications

References 59 publications

Expression Levels and Clinical Significance of Serum miR-497, CEA, CA24-2, and HBsAg in Patients with Colorectal Cancer

Expression Levels and Clinical Significance of Serum miR-497, CEA, CA24-2, and HBsAg in Patients with Colorectal Cancer

Disparities in Recommendations for Colorectal Cancer Screening Among Average-Risk Individuals: An Ecobiosocial Approach

Global, regional, and national burden of colorectal cancer and attributable risk factors, from 1990 to 2019: Updated results from the Global Burden of Disease Study 2019

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