The importance and relevance of peak bone mass in the prevalence of osteoporosis

Bonjour, Jean‐Philippe; Chevalley, Thierry; Ferrari, Serge; Rizzoli, René

doi:10.1590/s0036-36342009000700004

Cited by 165 publications

(171 citation statements)

References 71 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, this phenotype may be stage specific, as males tend to achieve peak bone mass later than females (Rizzoli et al 2001, Bonjour et al 2009, Stagi et al 2013; we cannot discard this augmented bone mass as it might occur at another time point. Further studies are warranted to determine how the absence of SR-BI alters the functions of adipocytes in female mice only and whether injection of leptin to male Scarb1-null mice mimics the bone phenotype of female Scarb1-null mice.…”

Section: Discussionmentioning

confidence: 86%

“…It is a well-known fact that men tend to achieve higher peak bone mass than do women, presumably due to the longer period of bone mass gain in the former (Rizzoli et al 2001). Bone accrual is also site specific within the same skeleton, with preferential bone mineral accumulation in the lumbar vertebrae and femoral neck (Rizzoli et al 2001, Bonjour et al 2009); these also happen to be common sites for osteoporotic fractures and show the greatest gender-related dimorphism (Raisz 2005, Bonjour et al 2009). Several determinants of peak bone mass are common to that of osteoporosis; factors that compromise bone mass are attributed to race, smoking, inactive lifestyle, malnutrition, and underlying metabolic disorders such as diabetes and atherosclerosis are often associated with lower bone mass (Leidig-Bruckner & Ziegler 2001, Sweet et al 2009, Stojanovic et al 2011.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Martineau

Martin-Falstrault

Brissette

et al. 2014

Journal of Endocrinology

View full text Add to dashboard Cite

A positive correlation between plasma levels of HDL and bone mass has been reported by epidemiological studies. As scavenger receptor class B, type I (SR-BI), the gene product of Scarb1, is known to regulate HDL metabolism, we recently characterized bone metabolism in Scarb1-null mice. These mice display high femoral bone mass associated with enhanced bone formation. As gender differences have been reported in HDL metabolism and SR-BI function, we investigated gender-specific bone alterations in Scarb1-null mice by microtomography and histology. We found 16% greater relative bone volume and 39% higher bone formation rate in the vertebrae from 2-month-old Scarb1-null females. No such alteration was seen in males, indicating gender-and region-specific differences in skeletal phenotype. Total and HDL-associated cholesterol levels, as well as ACTH plasma levels, were increased in both Scarb1-null genders, the latter being concurrent to impaired corticosterone response to fasting. Plasma levels of estradiol did not differ between null and WT females, suggesting that the estrogen metabolism alteration is not relevant to the higher vertebral bone mass in female Scarb1-null mice. Constitutively, high plasma levels of leptin along with 2.5-fold increase in its expression in white adipose tissue were measured in female Scarb1-null mice only. In vitro exposure of bone marrow stromal cells to ACTH and leptin promoted osteoblast differentiation as evidenced by increased gene expression of osterix and collagen type I alpha. Our results suggest that hyperleptinemia may account for the gender-specific high bone mass seen in the vertebrae of female Scarb1-null mice.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Martineau

Martin-Falstrault

Brissette

et al. 2014

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…After the end of the growth period, in early adulthood, the bone is still remodeled by resorption performed by osteoclasts and apposition by osteoblasts [24]. Acquisition of bone mineral continues throughout childhood and adolescence, reaching a lifetime maximum ('peak bone mass') in early adulthood [25]. In old adulthood (>65 years), decrease in bone mass density is usual, due to an unbalanced remodeling process [26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of changes in trabecular alveolar bone during growth using conventional panoramic radiographs

Pham

Kiliaridis

2011

Acta Odontologica Scandinavica

View full text Add to dashboard Cite

Objective. To assess changes of the alveolar trabecular bone during growth using panoramic radiographs and to detect possible differences in trabecular bone patterns when comparing individuals of various ages and genders. Materials and methods. Conventional panoramic radiographs of 18 young (eight females, 10 males) and 21 adult (12 females, nine males) subjects were taken at 2 years (T1) and 10 years (T2) after the end of orthodontic treatment. At T1, mean ages were 15.6 ± 0.9 years and 31.3 ± 9.7 years in the young and the adult groups, respectively. A three-scale visual analysis was used to evaluate bilaterally the alveolar bone trabeculation in the interdental spaces, from the distal side of the first mandibular premolar to the mesial side of the second lower molar. An analysis of variance (ANOVA), associated with t-tests whenever significance was found, was used to appraise the role of the age, the extent of the follow-up period and the gender on trabecular bone structure. Results. The adult group had a denser alveolar bone trabeculation, compared to the young group. This was also observed in the 8 years followup recordings among the adults, but no statistically significant differences were found in the growing individuals. No gender discrepancy was detected. Conclusions. From puberty to the middle age adulthood, denser alveolar bone trabeculation in the mandible seems to be related to the age. No differences were found between male and female subjects in the sample.

show abstract

“…The condition is a major public health problem in the Western countries and is projected to have a similar impact in the Middle East [1,2]. It has been suggested that peak Bone Mineral Density (BMD), which can be defined as the amount of bony tissue present at the end of the skeletal maturation, is a major determinant of osteoporotic fractures later on in life [3][4][5][6]. The probable importance of achieved peak bone mass for late life bone strength was first suggested by the cross-sectional observation of Newton-John and Morgan that the dispersion of bone mass values was not widened by age [7].…”

Section: Introductionmentioning

confidence: 99%

Protocol for Systematic Review: Peak Bone Mass Pattern in Different Parts of the World

Mohammadi¹,

Ebrahimi²,

Keshtkar³

et al. 2015

J Clinic Res Bioeth

View full text Add to dashboard Cite

Peak bone mass, which can be defined as the amount of bone tissue present at the end of the skeletal maturation, and also it is an important determinant of osteoporotic fracture risk. The peak bone mass of a given part of the skeleton is directly dependent upon both its genetics and environmental factors. Therefore, the aim of the proposed research is a comprehensive systematic assessment of the pattern of peak bone mass in different countries across the globe. The present article explains the protocol for conducting such a research.

show abstract

The importance and relevance of peak bone mass in the prevalence of osteoporosis

Abstract: Peak bone mass and osteoporosis risk Artículo de revisión

Cited by 165 publications

References 71 publications

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice

Evaluation of changes in trabecular alveolar bone during growth using conventional panoramic radiographs

Protocol for Systematic Review: Peak Bone Mass Pattern in Different Parts of the World

Contact Info

Product

Resources

About