The importance of pluripotential stem cells in benzene toxicity

Gill, David P.; Jenkins, Vernon K.; Kempen, Rene R.; Ellis, Sydney

doi:10.1016/0300-483x(80)90046-3

Cited by 44 publications

(17 citation statements)

References 14 publications

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“…There is evidence that non-cycling cells are resistant to the toxic effects of benzene (Gill et al 1980). The results of our studies provide evidence that the disparate responses of erythroid and granulocytic progenitor cells to benzene exposure are due to the different cycling characteristics of these cells in response to benzene exposure.…”

Section: Discussionmentioning

confidence: 97%

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Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure

Dempster

Snyder

1991

Arch Toxicol

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In previous work, we determined that granulocytic (CFU-GM) and erythroid (CFU-E) progenitor cell populations exhibited disparate responses to short-term benzene exposures. We now report on work investigating possible mechanisms for these observed disparate responses. Mice were exposed to either air or 10 ppm benzene for 6 h/d X 5 d. Immediately after the last exposure, mice were injected, i.v., with either saline or hydroxyurea (HU). The dose of HU was sufficient to kill hematopoietic cells in or near S-phase of the cell cycle and sufficient to synchronize the surviving populations of hematopoietic cells. Three days after benzene exposure, CFU-E numbers had declined to 50% of control values while CFU-GM numbers were equal to control values at this time. The benzene exposures were sufficient to double the percentage of CFU-E in S-phase but produced no such increase among CFU-GM. During 3 days of recovery from benzene exposure and HU treatment, the CFU-E population expanded 30-fold while the CFU-GM population expanded less than 3-fold. Following benzene exposure and HU treatment, both progenitor cells produced elevated numbers of their respective progeny. When CFU-E from benzene-exposed mice were cultured with varying concentrations of erythropoietin (EPO), the response at maximal EPO concentration was 66% of the response by control CFU-E. This strongly suggests that the CFU-E populations from benzene-exposed mice had been depleted of cells in or near S-phase.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 97%

“…Our working hypothesis was that the different responses of these cells to benzene exposures could be correlated with differences in the percentages of these cells in active cell cycle. Others have shown that cells must be actively cycling to be adversely affected by benzene exposure (Gill et al 1980;Irons 1981).…”

Section: Introductionmentioning

confidence: 99%

Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure

Dempster

Snyder

1991

Arch Toxicol

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“…There have been many reports on the effect of benzene on hematopoietic stem cells and early progenitors (24)(25)(26)(27)(28)(29)(30)(31). All studies show that benzene inhalation of 100 ppm or more reduces the number of hematopoietic stem cells and early progenitors.…”

Section: Discussionmentioning

confidence: 99%

Hematotoxicity and Carcinogenicity of Inhaled Benzene

Cronkite¹,

Drew²,

Inoue³

et al. 1989

Environmental Health Perspectives

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“…A administração de HQ in vivo promove neutrofilia (para revisão ver SNYDER, 2002SNYDER, , 2004, e reduz o número de células mononucleares no sangue periférico (GILL et al, 1980;SNYDER et al, 1980;GREEN et al, 1981;CRONKITE et al, 1984;FARRIS et al, 1997), na medula e em órgãos linfóides secundários (FARRIS et al, 1997;ROBINSON et al, 1997, VELASCO-LEZAMA et al, 2001. Além dos efeitos sob a produção e/ou maturação leucocitária, há evidências do papel da HQ sobre a atividade celular.…”

Section: Efeitos Tóxicos Da Hidroquinonaunclassified

Efeitos da hidroquinona sobre atividades funcionais da célula endotelial e de neutrófilos

Pinedo¹

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Hydroquinone (HQ) is a fenolic compound obtained after benzene metabolism, it is a component of cigarette, medicines, photographic developer, and it is also finding in some foods and medicinal herbs. Our research group has been shown that rats in vivo exposed to HQ present impaired leukocyte migration into lung during allergic or non-specific inflammation. In the present study, we investigate the effects of HQ on functional activities of neutrophils and endothelial cells (EC) involved in inflammation. Primary cultured EC was obtained from microcirculatory network of maleWistar rats, and treated with HQ (10 or 100 µM, two hours). After the treatments, EC was incubated in presence or absence of lipopolissacharide of E. coli (LPS; 2 µg/mL). Peritoneal neutrophils obtained four hours after local injection of oyster glycogen (10 mL, 1%) were incubated with HQ (5 or 10 µM, one hour)

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The importance of pluripotential stem cells in benzene toxicity

Cited by 44 publications

References 14 publications

Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure

Kinetics of granulocytic and erythroid progenitor cells are affected differently by short-term, low-level benzene exposure

Hematotoxicity and Carcinogenicity of Inhaled Benzene

Efeitos da hidroquinona sobre atividades funcionais da célula endotelial e de neutrófilos

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