2022
DOI: 10.4014/jmb.2207.07026
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The In Vitro and In Vivo Effect of Lipoxygenase Pathway Inhibitors Nordihydroguaiaretic Acid and Its Derivative Tetra-O-methyl Nordihydroguaiaretic Acid againstBrucella abortus544

Abstract: This study investigated the contribution of lipoxygenase (LOX) inhibitors, nordihydroguaiaretic acid (NDGA), tetra-O-methyl nordihydroguaiaretic acid (M 4 N) and zileuton (ZIL), and thromboxane A2 (TXA 2 ) inhibitor 4,5-diphenylimidazole (DPI) in the proliferation of Brucella abortus infection. None of the compounds affected the uptake of Brucella into the macrophages. We determined the effect of neutralizing leukotriene B4 (LTB4) receptor and showed that the uptake of the bacteria was inhibited at 30 min post… Show more

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Cited by 2 publications
(1 citation statement)
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“…In addition, four steps of viability, invasion, establishment, and dispersal have been reported to be required for successful Brucella infection of the host. Brucella can proliferate in a wide variety of mammalian cell types, including endothelial cells, fibroblasts, epithelial cells, and microglia, although they usually infect and replicate within phagocytic cells such as macrophages and dendritic cells (Reyes et al 2022).…”
Section: Virulence Factormentioning
confidence: 99%
“…In addition, four steps of viability, invasion, establishment, and dispersal have been reported to be required for successful Brucella infection of the host. Brucella can proliferate in a wide variety of mammalian cell types, including endothelial cells, fibroblasts, epithelial cells, and microglia, although they usually infect and replicate within phagocytic cells such as macrophages and dendritic cells (Reyes et al 2022).…”
Section: Virulence Factormentioning
confidence: 99%