The induction of bacterial mutation and hepatocyte unscheduled DNA synthesis by monosubstituted anilines

Thompson, Christina Z.; Hill, Leo E.; Epp, Janet K.; Probst, Gregory S.

doi:10.1002/em.2860050605

Cited by 73 publications

(22 citation statements)

References 11 publications

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“…In in vitro studies, positive bacterial mutagenicity by o-PD after S9 activation (Ames et al 1975;JETOC 1996) and positive mammalian clastogenicity of o-PD with cultured Chinese hamster lung cells (CHL/IU) without S9 activation have been reported (JETOC 1997). The induction of hepatocyte unscheduled DNA synthesis was also reported (Thompson et al 1983). In in vivo studies, the cytogenetic effect of o-PD in the mouse, Chinese hamster and guinea pig by the micronucleus test has been reported (Wild et al 1980).…”

Section: Discussionmentioning

confidence: 95%

Carcinogenicity of ortho-phenylenediamine dihydrochloride in rats and mice by two-year drinking water treatment

et al. 2012

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The carcinogenicity of ortho-phenylenediamine (o-PD) was examined by administrating o-phenylenediamine dihydrochloride (o-PD2HCl) in dinking water to groups of 50 F344/DuCrj rats and 50 Crj:BDF₁ mice of both sexes for 2 years. The drinking water concentration of o-PD2HCl was 0, 500, 1,000 or 2,000 ppm (wt/wt) for male rats; 0, 250, 500 or 1,000 ppm for female rats; 0, 500, 1,000 or 2,000 ppm for male mice; and 0, 1,000, 2,000 or 4,000 ppm for female mice. Two-year administration of o-PD2HCl produced a dose-dependent increase in the incidences of hepatocellular adenomas and carcinomas in rats of both sexes and in female mice, and hepatocellular adenomas in male mice. In mice, the incidences of hepatocellular adenomas were increased at the lowest dose used in both males and females. Metastasis from hepatocellular carcinomas of rats occurred predominantly in the lung. Incidences of transitional cell papillomas and carcinomas in the urinary bladder were noted in male rats administered 2,000 ppm, together with an increased incidence of papillary and/or nodular hyperplasia of transitional epithelium. In mice, the incidence of papillary adenomas in the gall bladder, which is rare in mice, was increased in both males and females administered 2,000 ppm. Thus, o-PD is carcinogenic in two species, i.e., rats and mice of both sexes.

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Section: Discussionmentioning

confidence: 95%

Carcinogenicity of ortho-phenylenediamine dihydrochloride in rats and mice by two-year drinking water treatment

et al. 2012

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“…For example 4-TFM -aniline has been shown to be carcinogenic (Thomson et al 1983). The herbicide Trifluralin has been studied in many organisms and ecosystems (Erkog and Menzer 1985;Golab et al 1979;Hamadi and Tewfik 1969;Lusby et al 1980;Sloan and Camper 1981;Stralka and Camper 1981;Williams 1977;Zeyer and Kearney 1983), F1uorodifen, a TFM-group and nitrosubstituted biarylether has also been investigated to some extent (Shimabukuro et aL 1982;Tewfik and Hamdi 1975) as well as Fluometuron (Rickard and Camper 1978) and the lampricide 3-TFM-4-nitrophenol (Schultz et a!.…”

Section: Discussionmentioning

confidence: 99%

Bacterial metabolism of side-chain-fluorinated aromatics: unproductive meta-cleavage of 3-trifluoromethylcatechol

Engesser

Rubio

Knackmuss

1990

Appl Microbiol Biotechnol

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Summary. Sixteen bacterial strains capable of de· grading alkyl benzenes and alkyl phenols were directly isolated from soil and water. The degradation pathways are discussed. Alkylcatechols are almost exclusively cleaved via meta-ring fission. Meta-cleavage of 3-trifluoromethyl-(TFM)-catechol was observed with all strains at different rates altbough the reaction rates compared to catechol as a substrate varied considerably. All 2-hydroxy-6-oxohepta-2,4-dienoic acid hydrolases investigated showed strong binding of 7,7,7-triOuoro-2-hydroxy-6-oxohepta-2,4-dienoic acid, the ring fi ssion product of 3-TFM-catechol. Turnover rates, however, were negligible indicating this compound to be a general dead-end metabolite during metabolism of TFM-substituted compounds via meta-cleavage pathways.

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“…It is introduced into the environment mainly through anthropogenic activities (Yoshida et al, 1988), such as during the manufacture of dyes, explosives, and pesticides (Fishbein, 1984;Hartter, 1984). NB has drawn considerable environmental concern (Hartter, 1984;Howard, 1989), and is now listed as a priority toxic pollutant by the US Environmental Protection Agency (Larson et al, 2000) because of its suspected carcinogenicity, mutagenicity, teratogenicity, and high toxicity (Gorontzy et al, 1993;Mansuy et al, 1978;Schackmann and Muller, 1991;Thompson et al, 1983). Yancheng Wetland, famous for its large areas of marshes, is surrounded by numerous chemical plants built in Yancheng (Jiangsu Province, China).…”

Section: Introductionmentioning

confidence: 99%

Soil Microbial Community Response to Nitrobenzene Exposure for aSpartinaWetland

Chen

Xiao

Liang

et al. 2013

Soil and Sediment Contamination: An International Journal

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To explore the response of the soil microbial community to nitrobenzene (NB) exposure in a Spartina marsh, a short-term (45 d) mesocosm study was conducted at three NB concentrations of (10, 50, and 100) mg kg −1 . Dry soil, sterile and unsterile controls were also compared. The ability of the microbes to biodegrade NB was studied in an effort to predict the outcome of NB in the mesocosm. The results indicated that a microbial community is capable of doing so. Microbial enumeration and enzyme assays showed that the fluctuations in microbial communities and polyphenol oxidase activities are related to the initial NB concentration. Moreover, cluster analyses through denaturing gradient gel electrophoresis (DGGE) revealed very similar patterns (95.5%) throughout the 45 d term, indicating that the microbial community regenerates when NB is exhausted. Although volatilization and photolysis were the major processes responsible for the reduction in NB in contaminated mesocosms and the microbial community regenerated at the end of incubation, the data indicate potential ecological risks in outfall areas even if the discharged wastewater complies with the national wastewater discharge standards.

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The induction of bacterial mutation and hepatocyte unscheduled DNA synthesis by monosubstituted anilines

Cited by 73 publications

References 11 publications

Carcinogenicity of ortho-phenylenediamine dihydrochloride in rats and mice by two-year drinking water treatment

Carcinogenicity of ortho-phenylenediamine dihydrochloride in rats and mice by two-year drinking water treatment

Bacterial metabolism of side-chain-fluorinated aromatics: unproductive meta-cleavage of 3-trifluoromethylcatechol

Soil Microbial Community Response to Nitrobenzene Exposure for aSpartinaWetland

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