The Influence of Ageing in Pseudoboehmites Synthesis

Munhoz, Antônio Hortêncio; Martins, Marcos Vinicius Surmani; Ussui, Valter; Cruz, Karina; Zandonadi, Alexandre R.; Miranda, Leila Figueiredo de

doi:10.4028/www.scientific.net/msf.727-728.1795

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…The crystallite size of boehmite and pseudoboehmite, and the specific surface area, has a strong correlation with the formation temperature of γ-Al 2 O 3 and the phase transition temperature of θ-to α-Al 2 O 3 9,18 . But comparing previous results 9,18 with the listed data in Table 5, the differences of the values in Table 5 were so small that that they promote no change in the temperature of the pseudoboehmite to γ-Al 2 O 3 and the θ-to α-Al 2 O 3 phase transformation. The phase transformation diminishes the value of specific surface area with the increase of temperature.…”

Section: Nitrogen Isotherms and Specific Surface Areamentioning

confidence: 72%

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Synthesis of pseudoboehmite – effect of acetate ion

et al. 2020

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Pseudoboehmite (AlOOH.xH 2 O) is one of the precursors of alumina. Its calcination produces different phases of alumina and at 1200º C the most stable phase, α-alumina, is formed. The synthesis of pseudoboehmite by the sol-gel process results in a product with high purity, high specific surface area, and high reproducibility. The aging of the pseudoboehmite at temperatures above room temperature results in pseudoboehmites with distinct properties. In this work we report the synthesis of pseudoboehmite by the sol-gel process, using aluminum nitrate and aluminum chloride as precursors, and investigate the effect of acetate ion on crystallinity, adsorption capacity, particle morphology, thermal properties and specific surface area. The X-ray diffraction data of the synthesized pseudoboehmites in the presence of the acetate ion revealed high quality nanoparticles.

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Section: Nitrogen Isotherms and Specific Surface Areamentioning

confidence: 72%

“…The results of the thermal analysis of sample 1 are presented in Figure 2 where one can observe the standard peaks associated with the pseudoboehmite 18,19 .…”

Section: Differential Thermal Analysis and Thermogravimetric Analysismentioning

confidence: 99%

Synthesis of pseudoboehmite – effect of acetate ion

et al. 2020

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“…The DTA and TG analysis of the pure pseudoboehmite indicated peaks characteristic of pseudoboehmite samples [34,35]. The sample has an endothermic peak at approximately 100 o C in DTA analysis due to the loss of water.…”

Section: Resultsmentioning

confidence: 99%

Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Preprint

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Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of low permeability across the gastrointestinal membrane. Based on experiments using nanoparticles of pseudoboehmite as a drug delivery system in vitro assays it was concluded that pseudoboehmite could be used for acyclovir release. We report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles. Pseudoboehmite was characterized by several techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content in the plasma of Wistar rats after 4 h administration. The toxicity of pseudoboehmite was also evaluated using the Caco-2 cell line (ATCC).

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“…Characterization of pseudoboehmite and the pseudoboehmite/acyclovir samples. The DTA and TG analysis of the pure pseudoboehmite indicated peaks characteristic of pseudoboehmite samples 34,35 . The sample has an endothermic peak at approximately 100 °C in DTA analysis due to the loss of water.…”

Section: Resultsmentioning

confidence: 99%

Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Sci Rep

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Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.

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The Influence of Ageing in Pseudoboehmites Synthesis

Cited by 9 publications

References 5 publications

Synthesis of pseudoboehmite – effect of acetate ion

Synthesis of pseudoboehmite – effect of acetate ion

Pseudoboehmite as a drug delivery system for acyclovir

Pseudoboehmite as a drug delivery system for acyclovir

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