The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.

Abstract

Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in theHL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).

Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone

“…Previous studies have confirmed the antiproliferative properties [ 12 , 31 ] and biochemical activity [ 32 , 33 ] of 3-formylchromone derivatives. Moreover, biological activity of copper (II) complexes of 3-formylchromone, was also described [ 21 ]; however, hydrazine and hydrazide derivatives of benzopyrones with fluorine substituents remain a poorly-analyzed group of compounds.…”