The Influence of Counterion Type and Temperature on Flory‐Huggins Binary Interaction Parameter in Polyelectrolyte Hydrogels

Сафронов, А. П.; Blyakhman, F. A.; Shklyar, T. F.; Terziyan, T. V.; Kostareva, Marina A.; Tchikunov, Sergey A.; Pollack, Gerald H.

doi:10.1002/macp.200800495

Cited by 15 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8(b)) by changing the polymer-solvent interaction parameters to v w 0 ¼ 0:43 and v a 0 ¼ 1:55. As suggested by Safronov et al [48], the interaction parameter may depend on the type of the counterions. Meanwhile, to fit the equilibrium stretch (k $ 8:7) at c 0 $ 10 À7 mol/l, we obtain Nt ¼ 0:66 Â 10 À3 for tC fix ¼ 0:1 by using Eq.…”

Section: Comparison With Experimentsmentioning

confidence: 91%

Salt-Induced Swelling and Volume Phase Transition of Polyelectrolyte Gels

Landis

Huang

2017

Journal of Applied Mechanics

View full text Add to dashboard Cite

A theoretical model of polyelectrolyte gels is presented to study continuous and discontinuous volume phase transitions induced by changing salt concentration in the external solution. Phase diagrams are constructed in terms of the polymer–solvent interaction parameters, external salt concentration, and concentration of fixed charges. Comparisons with previous experiments for an ionized acrylamide gel in mixed water–acetone solvents are made with good quantitative agreement for a monovalent salt (NaCl) but fair qualitative agreement for a divalent salt (MgCl2), using a simple set of parameters for both cases. The effective polymer–solvent interactions vary with the volume fraction of acetone in the mixed solvent, leading to either continuous or discontinuous volume transitions. The presence of divalent ions (Mg2+) in addition to monovalent ions in the external solution reduces the critical salt concentration for the discontinuous transition by several orders of magnitude. Moreover, a secondary continuous transition is predicted between two highly swollen states for the case of a divalent salt. The present model may be further extended to study volume phase transitions of polyelectrolyte gels in response to other stimuli such as temperature, pH and electrical field.

show abstract

Section: Comparison With Experimentsmentioning

confidence: 91%

Salt-Induced Swelling and Volume Phase Transition of Polyelectrolyte Gels

Landis

Huang

2017

Journal of Applied Mechanics

View full text Add to dashboard Cite

show abstract

“…The Flory-Huggins model is used to describe various polymeric systems, due to its simplicity and the possibility of its interaction parameter being determined experimentally by calorimetric techniques or, osmotic pressure, for example ( Safronov et al, 2009 ; Kim et al, 2010 ). The extended equation can be used as an initial model to describe and understand the forces involved in polymer-polymer and polymer-solvent interactions.…”

Section: Methodsmentioning

confidence: 99%

“…where a 1 and a 2 are the activity of component 1 and 2, respectively; V 1 , V 2 and V 3 are the volume per amount of matter of component 1, 2, and 3, respectively; χ 12 , χ 13 , and χ 23 are the Flory-Huggins parameter of component 1-2, 1-3, and 2-3, respectively. The Flory-Huggins model is used to describe various polymeric systems, due to its simplicity and the possibility of its interaction parameter being determined experimentally by calorimetric techniques or, osmotic pressure, for example (Safronov et al, 2009;Kim et al, 2010). The extended equation can be used as an initial model to describe and understand the forces involved in polymer-polymer and polymer-solvent interactions.…”

Section: Flory-huggins Parameter Of Interactionmentioning

confidence: 99%

Phase Diagram and Estimation of Flory-Huggins Parameter of Interaction of Silk Fibroin/Sodium Alginate Blends

Lopes

Moraes

Beppu

2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Silk fibroin (SF) and sodium alginate (SA) are natural polymers used to produce biomaterials. One of the strategies to improve the properties of these products is to prepare blends with them, which are partially miscible. Phase separation is observed, therefore, the thermodynamic analysis of this system is important to predict the final state and composition of this blends. This study explored blends with a different initial composition of SF, SA, and water (WA) at 25 • C and neutral pH. After phase separation, two phases were identified, one rich in SF and other rich in SA. The Flory-Huggins parameters of interaction of polymer-solvent and polymer-polymer were estimated using the extended equation and data of phase equilibrium, their values indicates the partial miscibility of the polymers.

show abstract

“…In fact, the effect of large ionic strengths on the response of poly(NIPAM)‐based gels and microgels has been reported by some experimentalists, but the underlying mechanisms have been scarcely discussed in depth. Regarding this point, the volume transitions of thermo‐responsive gels are often explained in terms of the classical formalism put forward by Flory and Rehner (FR) or its refinements, which in recent times have been particularly useful in studies of solvent mixtures or ion‐specific effects . However, the precise meaning of FR parameters as well as the limitations of the theory must be carefully identified to avoid misleading conclusions and improve the predictive power of such theoretical approaches .…”

Section: Introductionmentioning

confidence: 99%

Thermo‐responsive gels in the presence of monovalent salt at physiological concentrations: A Monte Carlo simulation study

Quesada‐Pérez

Ahualli

2014

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

In this work, slightly charged thermo-responsive gels in the presence of salt at concentrations close to physiological conditions have been simulated within a coarse-grained model widely used in the last decade. These simulations allow differentiate charge and salt effects, which are antagonist and coupled in many real systems because the degree of ionization might depend on the electrolyte concentration. An analysis in terms of the different contributions to osmotic pressure is also presented, which highlights the role played by excluded volume effects. In addition, our results also permit us to test some predictions based on the ideal Donnan equilibrium, a common assumption made to justify the swelling behavior of gels and microgels in the presence of salt. More specifically, simulations show that, for the slightly charged gels simulated here, such an assumption overestimates the concentration of salt inside collapsed gels and underestimates the excess of osmotic pressure associated to the additional electrolyte. KEYWORDS: computer modeling; drug delivery systems; gels; hydrogels; microgels; Monte Carlo simulations INTRODUCTION Thermo-responsive gels and microgels have gained considerable attention in different fields of biotechnology due to the ability of these materials to swell or shrink in response to temperature changes. Many researchers 1-3 have studied diverse applications of these gels, such as the controlled drug release. As potential therapeutic carriers, temperature-sensitive microgels should work at physiological conditions, that is, at ionic strengths of about 150 mM. Consequently, it should be desirable to explore how such ionic strengths can modify their thermal response.

show abstract

The Influence of Counterion Type and Temperature on Flory‐Huggins Binary Interaction Parameter in Polyelectrolyte Hydrogels

Cited by 15 publications

References 16 publications

Salt-Induced Swelling and Volume Phase Transition of Polyelectrolyte Gels

Salt-Induced Swelling and Volume Phase Transition of Polyelectrolyte Gels

Phase Diagram and Estimation of Flory-Huggins Parameter of Interaction of Silk Fibroin/Sodium Alginate Blends

Thermo‐responsive gels in the presence of monovalent salt at physiological concentrations: A Monte Carlo simulation study

Contact Info

Product

Resources

About