The influence of food intake and ambient temperature on the rate of thyroxine utilization.

Ingram, D. L.; Kaciuba-Uściłko, H.

doi:10.1113/jphysiol.1977.sp011960

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…Meals containing moderate amounts of carbohydrates (diets A and B) were associated with increases in serum T4 concentrations during the first several hours after meal completion. These observations are consistent with reports that T4 secretion rates and serum T4 concentrations are in¬ creased after the ingestion of meals containing carbo¬ hydrate by pigs (Ingram & Kaciuba-Uscilko, 1977;Ingram & Evans, 1980;Dauncey, Ingram, Macari & Ramsden, 1982), man (Spaulding, Chopra, Sherwin & Lyall, 1976;Danforth, Horton, O'Connell et al 1979) and cattle (Blum, Gingins, Schnyder et al 1979 ;Blum, Thomson & Bickel, 1979e). In addition, thyro¬ trophin (TSH) secretion has been reported to increase after feeding in rats (Hugues, Burger, Grouselle et al 1983) and man (Hugues, Burger, Pekary & Hershman, 1984).…”

Section: Discussionsupporting

confidence: 92%

Effects of dietary energy supply on serum thyroxine, tri-iodothyronine and insulin concentrations in young horses

Glade¹,

Reimers²

1985

Journal of Endocrinology

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The effects of meal ingestion on the circulating concentrations of the growth-regulating hormones thyroxine (T4), tri-iodothyronine (T3) and insulin were examined in weanling Thoroughbreds fed 70% (diet A), 100% (diet B) or 130% (diet C) of their energy and protein requirements. Peak insulin concentrations occurred 1, 2 and 3 h after the ingestion of diets C, B and A respectively. Increases in plasma glucose concentrations preceded the increases in serum insulin concentrations. Serum T4 concentrations increased after the ingestion of diets A and B and decreased after diet C. In contrast, serum T3 concentrations were unaffected by ingestion of diet A but increased after the ingestion of diets B and C. The increase was much greater and more rapid in the horses fed diet C. However, the decrease in T4 concentration was five times greater than the increase in T3 concentration. Accelerated insulin secretion after the ingestion of a meal high in energy (carbohydrate) content was therefore associated with decreased T4 secretion and accelerated T4 conversion to T3. However, 6 months later serum T4 and T3 concentrations were unaffected by meal ingestion.

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Section: Discussionsupporting

confidence: 92%

Effects of dietary energy supply on serum thyroxine, tri-iodothyronine and insulin concentrations in young horses

Glade¹,

Reimers²

1985

Journal of Endocrinology

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“…The changes seen in the disappearance rate of reverse T3 follow a similar trend to that reported earlier for (Ingram & Kaciuba-Uscilko, 1977), although the rate of disappearance of T4 was more sensitive, since a reduction in food intake from 4% to 2% induced a fall in clearance rate from plasma. This may be because the longer plasma half-life of T4 compared with that of reverse T3 makes any change more easily detectable.…”

Section: Resultssupporting

confidence: 78%

“…Labelled T3 and reverse T3 each in a dose of 25 µ were injected via the catheter and washed in by withdrawing and reinjecting blood several times before finally injecting 5 ml 0-9% NaCl solution. This procedure has previously been proved to be satisfactory (Ingram & Kaciuba-Uscilko, 1977). Subsequently 5 ml samples of blood were withdrawn at intervals into heparinized tubes and the plasma separated.…”

Section: Cathetersmentioning

confidence: 99%

The Influence of Energy Intake on the Metabolism of 3,5,3′-Tri-Iodothyronine and 3,3′,5′-Tri-Iodothyronine in Young Pigs

Ingram¹,

Ramsden²

1981

Journal of Endocrinology

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“…Although Ingram and Evans (1980) reported no effect of meal consumption on T4 concentrations in young pigs after a 12-h fast, they concluded that any changes in T4 secretion or utilization rates will be highly dependent on the sizes and caloric densities of the meals. Evans and Ingram (1977), Ingram and Kaciuba-Uscilko (1977), Ingram and Evans (1980) and Blum et al, (1980) reported increases in T4 secretion rates in growing pigs after increases in the amount and energy content of meals. Danforth et al (1979) reported a similar finding in humans.…”

Section: Discussionmentioning

confidence: 96%

Hormonal Responses to High and Low Planes of Nutrition in Weanling Thoroughbreds

Glade

Gupta

Reimers

1984

Journal of Animal Science

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Growth-related skeletal diseases in young horses have been associated with high planes of nutrition, although the mechanisms underlying such an association have not been determined. It is likely that nutrition-induced effects on growth rate or growth quality involve the endocrine system. Hormonal and metabolic responses to the ingestion of meals containing either 80% (diet A) or 160% (diet B) of National Research Council energy and protein recommendations were examined in eight Thoroughbred weanling horses after 3 wk of dietary adaptation. After 24 h fasts, prefeeding serum concentrations of thyroxine (T4) and insulin and plasma concentrations of glucose, total protein, total triglycerides, creatinine, Ca and P were similar regardless of which diet the horses had been consuming. Serum cortisol concentrations were higher (P less than .05) in horses when fasted from diet B. Thyroxine, insulin and glucose concentrations increased during ingestion of both meals. During the first hour after ingestion of diet A, T4 concentrations increased to about 150% of fasting concentrations, whereas after diet B, T4 concentrations decreased to about 85% of fasting concentrations. Concentrations of T4 were not different from fasting concentrations 4 h after the ingestion of both diets. Glucose concentrations increased during the first hour postprandially, from about 105 mg/dl to about 165 mg/dl. However, glucose decreased more rapidly after ingestion of diet B. Serum insulin concentrations increased more rapidly after ingestion of diet B. Cortisol concentrations decreased after both meals, and the concentrations of the other metabolites measured were not affected by diet level or by meal consumption.(ABSTRACT TRUNCATED AT 250 WORDS)

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The influence of food intake and ambient temperature on the rate of thyroxine utilization.

Cited by 20 publications

References 22 publications

Effects of dietary energy supply on serum thyroxine, tri-iodothyronine and insulin concentrations in young horses

Effects of dietary energy supply on serum thyroxine, tri-iodothyronine and insulin concentrations in young horses

The Influence of Energy Intake on the Metabolism of 3,5,3′-Tri-Iodothyronine and 3,3′,5′-Tri-Iodothyronine in Young Pigs

Hormonal Responses to High and Low Planes of Nutrition in Weanling Thoroughbreds

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