The influence of glycosaminoglycans on IL-8-mediated functions of neutrophils

Pharmacology of Heparin and Related Drugs

“…Heparin binding site on the C-terminal a-helix and proximal loop (Schlorke et al, 2012;Möbius et al, 2013) …”

The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis

“…Moreover, increased concentrations of GAGs have been found in BALF from children with CF (Bhaskar et al, 1998;Hilliard et al, 2007) and secretion of HS (Solic et al, 2005), CS (Khatri et al, 2003;Rahmoune et al, 1991) and hyaluronic acid (Sahu, 1980;Wyatt et al, 2002) is markedly increased in bronchial cells and CF tissues. GAGs have also been shown to influence the chemokine profile of the CF lung by binding and stabilizing CXCL8 in its active form thus promoting the activation and infiltration of neutrophils (Reeves et al, 2011b;Schlorke et al, 2012).…”

Current structural biology of the heparin interactome

“…The chemokine (cytokine) types most analyzed in the current structural biology of heparin interactome are interleukin-8 (IL-8 or cysteine-amino acid-cysteine ligand (CXCL8)) as the leader of the group [10][11][12], followed by CXCL12 [13,14 ], and then CXCL1 [15 ], CXCL11 [16], interferon-gamma [17], IL-10 [18 ], monocyte chemoattractant protein-1 (CCL2) [12], and the viral macrophage inflammatory protein-II [19].…”