The Influence of Ingested Mineral Oil upon the Development of an Essential Fatty Acid Deficiency in the Rat

Abstract

Scientific literature contains many references to the influ ence of ingested mineral oil upon the absorption of certain of the vitamins. As early as 1927, Dutcher et al. showed that a mixture of mineral oil with butterfat was ineffective in curing vitamin A-deficient rats, and additional work by this group (Dutcher et al., '33, '34) attributed this result to the solvent action of mineral oil on carotene. This effect of mineral oil on carotene utilization has been confirmed with both rats and man by a number of other workers (

Study of the lipid requirements of the young dairy calf

“…Bacon et al(8) foimd that if mineral oil at levels below five per cent is added to a low-fat diet, fatty acid deficiencies result and growth ceases in about 12 v/eeks. When ten per cent mineral oil was added to a low-fat diet, growth failure in the rats occurred in two to three weeks.The data are not so conclusive in the case of the male.The administration of linoleate at a level of 60 mg. daily did not change the slov?…”