The Influence of KIR Gene Polymorphisms and KIR-ligand Binding on Outcomes in Hematologic Malignancies following Haploidentical Stem Cell Transplantation: A Comprehensive Review

Rostami, Tahereh; Ganjalikhani‐Hakemi, Mazdak; Bakhtiari, Tahereh; Ahmadvand, Mohammad; Salmaninejad, Arash; Ghaderi, Afshin; Yaghmaie, Marjan; Sadeghi, Hojjat; Mousavi, Seyed Asadollah

doi:10.2174/1568009623666230523155808

Cited by 1 publication

(1 citation statement)

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“…Lastly, NCT02481297 is assessing the safety of Lirilumab in combination with Rituximab in patients with r/r CLL. Additionally, genetic variability in KIRs due to allelic polymorphisms has been implicated in the variability of patients’ responses in allo- and haptoidentical HCT ( 154 ). Thus, a number of current studies aim to better understand the importance of donor selection based on HLA and KIR profile matching, which could open up more avenues toward the therapeutic addition of anti-KIR ICI.…”

Section: Other Targetable Checkpoint Moleculesmentioning

confidence: 99%

Checkpoint inhibition in hematologic malignancies

Tsumura,

Levis,

Tuscano

2023

Front. Oncol.

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Checkpoint inhibitor therapy has emerged as an effective therapeutic strategy for many types of malignancies, especially in solid tumors. Within the last two decades, numerous monoclonal antibody drugs targeting the CTLA-4 and PD-1/PD-L1 checkpoint pathways have seen FDA approval. Within hematologic malignancies, Hodgkin Lymphoma has seen the greatest clinical benefits thus far with more recent data showing efficacy in the front-line setting. As our understanding of checkpoint inhibition expands, using these pathways as a therapeutic target has shown some utility in the treatment of other hematologic malignancies as well, primarily in the relapsed/refractory settings. Checkpoint inhibition also appears to have a role as a synergistic agent to augment clinical responses to other forms of therapy such as hematopoietic stem cell transplant. Moreover, alternative checkpoint molecules that bypass the well-studied CTLA-4 and PD-1/PD-L1 pathways have emerged as exciting new therapeutic targets. Most excitingly is the use of anti-CD47 blockade in the treatment of high risk MDS and TP-53 mutated AML. Overall, there has been tremendous progress in understanding the benefits of checkpoint inhibition in hematologic malignancies, but further studies are needed in all areas to best utilize these agents. This is a review of the most recent developments and progress in Immune Checkpoint Inhibition in Hematologic Malignancies in the last decade.

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Section: Other Targetable Checkpoint Moleculesmentioning

confidence: 99%