In order to better determine the applicable working conditions of Al-Si alloy cylinder liners and cast-iron cylinder liners, their tribological performance and scuffing resistance are discussed in this paper. After wear and scuffing tests, it was found that cast-iron cylinder liners had better wear resistance and better scuffing resistance, but poor friction performance. Al-Si alloy cylinder liners had weaker wear resistance and scuffing resistance, but excellent friction performance. The wear mechanism of cast-iron cylinder liners is slight adhesive wear, and they are suitable for traditional fuel engines and turbocharged engines with high load, high power, and high stability. The wear mechanism of Al-Si alloy cylinder liners was a mixture of adhesive wear and abrasive wear, and they are suitable for engines that are lightweight, efficient, and energy-saving, and operate at high speeds.