The Influence of Smoking on Pancreatic Function in Man

Brown, Pamela

doi:10.5694/j.1326-5377.1976.tb130184.x

Cited by 26 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since bicarbonate is the most important buffer constituent of saliva (13), the lower buffer effect of smokers' saliva most probably reflected a lower concentration of HCO3 . An interesting parallel to the present fmdings may therefore be drawn from several studies on pancreatic juice, for which a significantly lower bicarbonate concentration has been reported in smokers (14,15). A systemic influence on the salivary buffer effect seemed further implicated, since no differences between smokers and non-smokers as regards secretion rate were observed.…”

Section: Discussionsupporting

confidence: 66%

Secretion rate, buffer effect and number of lactobacilli and Streptococcus mutans of whole saliva of cigarette smokers and non‐smokers

Heintze

1984

European J Oral Sciences

View full text Add to dashboard Cite

– Secretion rate and buffer effect of resting and stimulated whole saliva, and number of lactobacilli and S. mutans in stimulated whole saliva were determined for 182 subjects, of whom 109 were cigarette smokers. For secretion rate, no difference between smokers and non‐smokers was observed. The median buffer effect was significantly lower in smokers. The median numbers of lactobacilli and S. mutans were significantly higher in saliva of smokers. The number of lactobacilli was significantly correlated with number of cigarettes smoked per day. About 40% of the smokers had 106 S. mutans CFU/ml, which was more than twice that of non‐smokers. In a complementary study on 20 smokers, the immediate influence of cigarette smoking on secretion rate and buffer effect of stimulated whole saliva was investigated for 1 h after smoking. No significant effect was found.

show abstract

Section: Discussionsupporting

confidence: 66%

Secretion rate, buffer effect and number of lactobacilli and Streptococcus mutans of whole saliva of cigarette smokers and non‐smokers

Heintze

1984

European J Oral Sciences

View full text Add to dashboard Cite

show abstract

“…Our findings agree with those of previous investigators that habitual smokers had significantly lower peak PF [HCO 3 − ] [39, 40]. A recent study also found that current cigarette smoking was independently associated with secretory dysfunction (defined as [HCO 3 − ] <80 mEq/L) and calcifications [26].…”

Section: Discussionsupporting

confidence: 93%

“…Cigarette smoke exposure has been shown to induce expression of pro-fibrotic inflammatory mediators in animal models [28]. There is also evidence to suggest that cigarette smoking may impair pancreatic secretory function even in the absence of overt pancreatic disease [26, 38, 39, 40]. Further studies in smokers and non-smokers are warranted.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study also found that current cigarette smoking was independently associated with secretory dysfunction (defined as [HCO 3 − ] <80 mEq/L) and calcifications [26]. Human studies generally agree that smoking appears to acutely impair duct cell secretory function [38, 39, 40, 42]. Canine studies have shown that intravenous nicotine generally appeared to suppress duct cell function; however, these experiments did note variable responses in pancreatic fluid volume, secreted bicarbonate, and bicarbonate concentration [43, 44, 45].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cigarette Smoking Impairs Pancreatic Duct Cell Bicarbonate Secretion

Kadiyala

Lee

Banks

et al. 2013

JOP. Journal of the Pancreas

View full text Add to dashboard Cite

“…The mechanism of this effect of nicotine on the pancreas remains elusive and has not been established yet. We have designed the current study in freshly isolated pancreatic acinar cells to determine the direct effect of nicotine on exocrine secretory capacity by manipulating calcium selective agents and mitogen activated protein kinase (MAPK) inhibitors since in-vivo studies have shown that nicotine at pharmacological concentrations decrease exocrine function via suppression of amylase release [7,11,13-15]. It is suspected that these effects are most likely mediated via calcium regulated pathways [9,16,17].…”

Section: Introductionmentioning

confidence: 99%

Effect of nicotine on exocytotic pancreatic secretory response: role of calcium signaling

Chowdhury¹,

Udupa²

2013

Tobacco Induced Diseases

View full text Add to dashboard Cite

BackgroundNicotine is a risk factor for pancreatitis resulting in loss of pancreatic enzyme secretion. The aim of this study was to evaluate the mechanisms of nicotine-induced secretory response measured in primary pancreatic acinar cells isolated from Male Sprague Dawley rats. The study examines the role of calcium signaling in the mechanism of the enhanced secretory response observed with nicotine exposure.MethodsIsolated and purified pancreatic acinar cells were subjected to a nicotine exposure at a dose of 100 μM for 6 minutes and then stimulated with cholecystokinin (CCK) for 30 min. The cell’s secretory response was measured by the percent of amylase released from the cells in the incubation medium Calcium receptor antagonists, inositol trisphosphate (IP3) receptor blockers, mitogen activated protein kinase inhibitors and specific nicotinic receptor antagonists were used to confirm the involvement of calcium in this process.ResultsNicotine exposure induced enhanced secretory response in primary cells. These responses remained unaffected by mitogen activated protein kinases (MAPK’s) inhibitors. The effects, however, have been completely abolished by nicotinic receptor antagonist, calcium channel receptor antagonists and inositol trisphosphate (IP3) receptor blockers.ConclusionsThe data suggest that calcium activated events regulating the exocytotic secretion are affected by nicotine as shown by enhanced functional response which is inhibited by specific antagonists… The results implicate the role of nicotine in the mobilization of both intra- and extracellular calcium in the regulation of stimulus-secretory response of enzyme secretion in this cell system. We conclude that nicotine plays an important role in promoting enhanced calcium levels inside the acinar cell.

show abstract

The Influence of Smoking on Pancreatic Function in Man

Cited by 26 publications

References 9 publications

Secretion rate, buffer effect and number of lactobacilli and Streptococcus mutans of whole saliva of cigarette smokers and non‐smokers

Secretion rate, buffer effect and number of lactobacilli and Streptococcus mutans of whole saliva of cigarette smokers and non‐smokers

Cigarette Smoking Impairs Pancreatic Duct Cell Bicarbonate Secretion

Effect of nicotine on exocytotic pancreatic secretory response: role of calcium signaling

Contact Info

Product

Resources

About