The influence of substitution type on the performance of methylcellulose and hydroxypropylmethycellulose in gels and matrices

Mitchell, Karen; Ford, James L.; Armstrong, David J.; Elliott, Paul I. P.; Hogan, John E.; Rostron, C.

doi:10.1016/0378-5173(93)90085-t

Cited by 85 publications

(39 citation statements)

References 19 publications

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“…A report from Mitchell et al on propranolol hydrochloride challenges the principle that the substitution type may affect the release of soluble drugs. Their water uptake study indicated that uptake may not be significantly different among various types of HPMC, resulting in drug release rates being independent of the substitution type (93). Drug release profiles from HPMC hydrophilic matrices are generally first-order for highly soluble drugs or zero-order for insoluble drugs.…”

Section: Hydrophilic Matricesmentioning

confidence: 99%

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

et al. 2011

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In addition to a number of highly soluble drugs, most new chemical entities under development are poorly water-soluble drugs generally characterized by an insufficient dissolution rate and a small absorption window, leading to the low bioavailability. Controlled-release (CR) formulations have several potential advantages over conventional dosage forms, such as providing a uniform and prolonged therapeutic effect to improve patient compliance, reducing the frequency of dosing, minimizing the number of side effects, and reducing the strength of the required dose while increasing the effectiveness of the drug. Solid dispersions (SD) can be used to enhance the dissolution rate of poorly water-soluble drugs and to sustain the drug release by choosing an appropriate carrier. Thus, a CR-SD comprises both functions of SD and CR for poorly water-soluble drugs. Such CR dosage forms containing SD provide an immediately available dose for an immediate action followed by a gradual and continuous release of subsequent doses to maintain the plasma concentration of poorly water-soluble drugs over an extended period of time. This review aims to summarize all currently known aspects of controlled release systems containing solid dispersions, focusing on the preparation methods, mechanisms of action and characterization of physicochemical properties of the system.

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Section: Hydrophilic Matricesmentioning

confidence: 99%

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

et al. 2011

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“…분자량이 다른 4종의 지속성 고분자 HPMC로 제조된 비타민 C 지속성 정제의 생체 외 용출 거동은 4종의 HPMC를 사용한 모든 처방에서 12시간 이상의 지속 효과를 나타냄을 확인하였으 며, HPMC의 분자량 차이에 따른 용출률의 차이 (33)(34)(35) 문 헌…”

Section: 점도별 용출unclassified

Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets

Hyun

Hong

Lee

et al. 2012

Korean Journal of Food Science and Technology

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The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.

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“…The kinetics of drug release from HPMC matrices show a strong dependence on drug solubility, but release rates can also be modulated by changing the polymer content, and through characteristics such as polymer viscosity [12][13][14] and substitution level [15,16]. Different commercially available grades of HPMC are marketed for this purpose [17].…”

Section: Introductionmentioning

confidence: 99%

The influence of polymer content on early gel-layer formation in HPMC matrices: The use of CLSM visualisation to identify the percolation threshold

Mason

Campiñez

Pygall

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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The influence of substitution type on the performance of methylcellulose and hydroxypropylmethycellulose in gels and matrices

Cited by 85 publications

References 19 publications

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets

The influence of polymer content on early gel-layer formation in HPMC matrices: The use of CLSM visualisation to identify the percolation threshold

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