The inheritance of slipped upper femoral epiphysis

Idiopathic Slipped Capital Femoral Epiphysis in Amish Children

“…The 39% prevalence of a positive family history (nine of the twenty-three children for whom a family history was recorded) in this study is much higher than the prevalences of 9% (four of forty-five) 32 and 14.5% (thirty-one of 214 ) 33 in two other population studies (p = 0.002). Rennie postulated that inbreeding was the reason for the increased familial incidence of slipped capital femoral epiphysis in northeast Scotland 33 . The rural, agricultural population of northeast Scotland at the time of his study had very definite geographical boundaries with a stable community, not unlike that seen in the Amish population in the United States today.…”

“…Consanguinity is specifically known to enhance the phenotypic expression of autosomal recessive disorders. Slipped capital femoral epiphysis is not, to the best of our knowledge, a standard autosomal recessive disorder, although it has been postulated to be autosomal recessive with low penetrance 33 . The 39% prevalence of a positive family history (nine of the twenty-three children for whom a family history was recorded) in this study is much higher than the prevalences of 9% (four of forty-five) 32 and 14.5% (thirty-one of 214 ) 33 in two other population studies (p = 0.002).…”

“…Slipped capital femoral epiphysis is not, to the best of our knowledge, a standard autosomal recessive disorder, although it has been postulated to be autosomal recessive with low penetrance 33 . The 39% prevalence of a positive family history (nine of the twenty-three children for whom a family history was recorded) in this study is much higher than the prevalences of 9% (four of forty-five) 32 and 14.5% (thirty-one of 214 ) 33 in two other population studies (p = 0.002). Rennie postulated that inbreeding was the reason for the increased familial incidence of slipped capital femoral epiphysis in northeast Scotland 33 .…”

“…Data on family history were not gathered for the control group in the multicenter study 11 . However, the rates of a positive family history were reported to be 9% and 14.5% in two literature studies 32,33 , performed in Scotland and Sweden. These studies likely included all white children, similar to the control group in the present study.…”

The Epidemiology and Demographics of Slipped Capital Femoral Epiphysis

“…Familial SCFE was first noted in the English language literature in 1940 [64] with many more subsequent descriptions [65–74, 76–80, 83–87]. Proposed patterns of genetic transmission include X-linked dominant, autosomal dominant with variable penetrance, and autosomal recessive [68, 71, 73, 77]. HLA phenotype studies in children demonstrate no common findings (Table 7) [74, 75, 79–82, 86].…”