The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells

Lu, Huixia; Hu, Hong; Yang, Yi; Li, Shaobo

doi:10.1016/j.tjog.2020.01.014

Cited by 14 publications

(9 citation statements)

References 17 publications

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“…Hyperplasia of endometriotic cells is driven by aberrant autophagy, which is also upregulated by hypoxia. Entometriotic tissue usually occurs in anoxic conditions, which promotes autophagic processes and ROS production [ 44 ].…”

Section: Theories Of Endometriosismentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

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Endometriosis is a chronic, estrogen-dependent, inflammatory condition that is defined as the presence of endometrial glands and stroma outside the uterine cavity. Despite the progress in research into the mechanisms leading to the development of endometriosis, its cause has not yet been established. It seems to be possible that the formation of oxidative stress may be one of the main causes of the development of endometriosis. There is much research that studies the potential role of trace elements in the appearance of endometrial-like lesions. Most studies focus on assessing the content of selected trace elements in the blood, urine, or peritoneal fluid in women with endometriosis. Meanwhile, little is known about the content of these elements in endometrial-like implants, which may be helpful in developing the theory of endometriosis. Investigations that are more comprehensive are needed to confirm a hypothesis that some trace elements play a role in the pathomechanism of endometriosis.

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Section: Theories Of Endometriosismentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

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“…N-acetylcysteine is a key substrate for the production of glutathione -an antioxidant compound responsible for detoxification processes [21]. It also affects the quality of oocytes and sperm, protecting DNA against free radicals [22]. In a study conducted by Iñaki et al 92.7% of the patients who assessed pain intensity > 4 on the visual analogue scale (VAS), 3 months after treatment, 87.2% declared pain relief [23].…”

Section: Scientific Collection «Interconf» | № 49 481mentioning

confidence: 99%

Endometriosis and Oxidative-Antioxidative Imbalance Status. The Role of Flavonoids, Curcumin and N-Acetylcysteine

et al. 2021

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Endometriosis is a silent, unseen and painful female illness which is characterized by the presence of glands and stroma outside the uterine cavity. Approximately one in ten women in a reproductive age around the world suffer from endometriosis of whom nearly half is treated due to infertility. The pathogenesis and mechanisms that determines the occurence of the disease are still unknown. Immunological factors have been observed in the initiation and development of endometriosis. An imbalance between reactive oxygen species (molecules having an unpaired electron) and antioxidants leads to the upregulation of metalloproteinases, prostaglandins, cytokines and chemokines.

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“…This process is however imperfect, as oxidation byproducts may be highly reactive, therefore degrading functional biomolecules which come in contact with them [5,9,10]. These reactive byproducts are the often-demonized reactive oxygen species (ROS), which include oxygen-bearing free radicals and other reactive compounds [11,12]. An overview of ROS and other reactive chemicals is showcased in Table 1.…”

Section: Introduction 11 the Principles Of Antioxidant Thermodynamics In Biological Systemsmentioning

confidence: 99%

“…Albeit ROS are widely known for their negative effects on organisms, these compounds do have remarkable importance to sustain life. Although such statement might be seemingly paradoxical, oxidative stress and ROS buildup are essential to proper inflammatory response as well as immunologic defense [8,11,12]. Moreover, the relevance of ROS in the natural workings of cell physiology is still being discovered, since these compounds have been linked to many biochemical pathways and cell signaling processes.…”

Section: Introduction 11 the Principles Of Antioxidant Thermodynamics In Biological Systemsmentioning

confidence: 99%

“…Moreover, the relevance of ROS in the natural workings of cell physiology is still being discovered, since these compounds have been linked to many biochemical pathways and cell signaling processes. For instance, superoxide anion showcases affinity to sulfur residues bound to iron coordination complexes as the heme in cytochromes, while some non-radical ROS may showcase affinity to exposed sulfur-bearing amino acids such as cysteine, thence selectively targeting these moieties [11][12][13]. Therefore, the true concept behind antioxidants is not the full disruption of oxidative stress, but the balance of this natural phenomenon toward proper homeostasis.…”

Section: Introduction 11 the Principles Of Antioxidant Thermodynamics In Biological Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Thermodynamics and Kinetics ofCamellia sinensisExtracts and Constituents: An Untamed Antioxidant Potential

Thomaz¹

2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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Given the relevance of impairing reactive oxygen species (ROS) buildup in tissues, the use of exogenous antioxidants is highly regarded as a valid prophylaxis against oxidative stress and its deleterious effects on organisms. In this regard, Camelia sinensis uses as a remarkable antioxidant source have been reported in various folk and standard medicine systems around the world. In this chapter, the thermodynamics and kinetics of Camelia sinensis constituents is concisely discussed focusing on the implications of its redox profiling toward antioxidant capacity. Notwithstanding, the biological repercussion of ROS reduction as well as its therapeutic potential is also addressed to provide readers a basic background on the relevance of investigating the physicochemical features of medicinal plants.

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The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells

Cited by 14 publications

References 17 publications

Brief Review of Endometriosis and the Role of Trace Elements

Brief Review of Endometriosis and the Role of Trace Elements

Endometriosis and Oxidative-Antioxidative Imbalance Status. The Role of Flavonoids, Curcumin and N-Acetylcysteine

Thermodynamics and Kinetics ofCamellia sinensisExtracts and Constituents: An Untamed Antioxidant Potential

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