The Inhibitory Effect of Echinacea purpurea and Echinacea pallida on BT-549 and Natural Killer Cells

Driggins, S. Nicole; Whalen, Margaret M.; Myles, Elbert L.

doi:10.15406/mojcsr.2017.04.00091

MOJCSR

2017

DOI: 10.15406/mojcsr.2017.04.00091

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The Inhibitory Effect of Echinacea purpurea and Echinacea pallida on BT-549 and Natural Killer Cells

S. Nicole Driggins

Margaret M. Whalen

Elbert L. Myles

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Cited by 3 publications

(1 citation statement)

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“…It exists in chicory with favorable bioactive effects, such as anticancer, anti-inflammatory, antioxidant, and immunological impacts. [7][8][9][10][11] Numerous researches have proved that cichoric acid plays a noteworthy role in fighting AD. For instance, cichoric acid can reduce AD-related brain damage via inhibiting oxidative stress.…”

mentioning

confidence: 99%

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

Li¹,

Liu²,

Yin³

et al. 2022

J. Electrochem. Soc.

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Chicoric acid (CA), a phenolic acid from chicory, is regarded as a powerful ingredient against oxidative stress and obesity. It's believed to be a promising drug candidate as its healing features prevent memory loss. However, existent methods for CA detection limit its practical applications in purification and further pharmacological study due to lack of accuracy. Therefore, it is crucial to find a forceful approach to precisely analyze cichoric acid for anti-AD research. In this work, we reported a facile method to synthesize Setaria-like trimetallic nanodendrites (G-PP NDs) in a non-compacted core-shell shape with high electrocatalytic activity. In addition, a sensitive biosensor to detect cichoric acid rapidly and accurately has been developed based on G-PP NDs and aminated reduced graphene oxide flakes (NH2-RGO@G-PP NDs). Owing to the great conductivity of NH2-RGO and significant electrochemical performance of G-PP NDs, the obtained sensor exhibited admirable capacities with a low LOD of 0.038 μM. It displayed a high sensitivity, rapid response, and excellent long-term stability, which made it accomplish the measurements CA in chicory samples. The proposed sensor is an auspicious tool for quality control and analysis of metabolism to investigate the beneficial impacts of CA as a functional ingredient to combat AD.

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mentioning

confidence: 99%

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

Li¹,

Liu²,

Yin³

et al. 2022

J. Electrochem. Soc.

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Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Espinosa-Paredes

Cornejo-Garrido

Moreno-Eutímio

et al. 2020

Nutrition and Cancer

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Enhancing the secondary metabolite and anticancer activity of Echinacea purpurea callus extracts by treatment with biosynthesized ZnO nanoparticles

Karimi

Behbahani

Dini

et al. 2018

Adv. Nat. Sci: Nanosci. Nanotechnol.

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This investigation was done to study the effect of green synthesized ZnO nanoparticles (NPs) on the anticancer activity of callus extracts of Echinacea purpurea in comparison with commercial ZnO microparticles (MPs). Leaf explants of E. purpurea were grown on the Murashinge and Skoog (MS) medium containing different concentrations of 2,4-dichlorophenoxyacetic acid (2,4-D) and naphthalene acetic acid (NAA). Callus induction at optimum concentrations were considered under both light and dark conditions. Among media with diverse concentrations of 2,4-D and NAA, fast-growing friable callus was started within three weeks after culturing on the MS medium containing 2.0 mg . After adding different concentrations of synthesized ZnO NPs and ZnO MPs to the culture medium containing 2 mg , the effect of ZnO NPs on the anticancer activity of plant extracts and callus biomass was found positive contrary to the control and ZnO MPs. However, these extracts did not have any cytotoxic activity on MCF-10 cells and peripheral blood monolayer cells. The frequency and intensity of CD4 expression on peripheral blood monolayer cells was not increased in the presence of all extracts. The highest flavonoid production of the extracts was also achieved in calli treated with different concentration of ZnO NPs. Therefore, it can be concluded that there is a direct relationship between the anticancer activity of E. purpurea and flavonoid contents.

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The Inhibitory Effect of Echinacea purpurea and Echinacea pallida on BT-549 and Natural Killer Cells

Cited by 3 publications

References 25 publications

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Enhancing the secondary metabolite and anticancer activity of Echinacea purpurea callus extracts by treatment with biosynthesized ZnO nanoparticles

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The Inhibitory Effect of Echinacea purpurea and Echinacea pallida on BT-549 and Natural Killer Cells

Cited by 3 publications

References 25 publications

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH2-RGO Flakes

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH2-RGO Flakes

Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Enhancing the secondary metabolite and anticancer activity of Echinacea purpurea callus extracts by treatment with biosynthesized ZnO nanoparticles

Contact Info

Product

Resources

About

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes

An Electrochemical Biosensor for Detection of Cichoric Acid as an Anti-Alzheimer’s Disease Agent in Chicory Samples Based on Setaria-Like Trimetallic Nanodendrites Decorated NH₂-RGO Flakes