2010
DOI: 10.1016/j.fitote.2010.07.024
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The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues

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Cited by 115 publications
(102 citation statements)
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“…However, this reduction only was significant in the honey group compared to the AA-colitis group. Honey and its extracts significantly decreased edema perhaps through the suppression of NO and PGE2 production as molecular vasodilators (28). Previous studies have not reported the effects of preadministration of honey alone and honey + SP on colon weight/length ratio.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…However, this reduction only was significant in the honey group compared to the AA-colitis group. Honey and its extracts significantly decreased edema perhaps through the suppression of NO and PGE2 production as molecular vasodilators (28). Previous studies have not reported the effects of preadministration of honey alone and honey + SP on colon weight/length ratio.…”
Section: Discussionmentioning
confidence: 96%
“…For instance, polyphenols (e.g. caffeic acid, ellagic acid, chrysin, and quercetin) by down -regulation of NF-κB decreased the biosynthesis of iNOS and inhibited NO production (28,35). Gallic acid, a phenolic compound in honey, can decline lipid peroxidation by free radical scavenging (36).…”
Section: Discussionmentioning
confidence: 99%
“…The first phase (1 h) involves the release of serotonin and histamine and the second phase (> 1 h) is mediated by cyclooxygenase products and the continuity between the two phases is provided by kinins [15,16]. Prostaglandins (PG) (PGE2) play an essential role in inflammation [17].…”
Section: Discussionmentioning
confidence: 99%
“…The honey was certified to be pure after it was analyzed at the Department of Molecular Medicine of the Faculty of Medicine, University of Malaya. Many studies have been conducted on this honey to show its superior qualities, having powerful antioxidant, antiinflammatory, and antibacterial activities (11)(12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 99%
“…Many studies have been done to explain the various properties found in honey that contribute to their antioxidant, antiinflammatory, antibacterial, antiviral, antiulcerogenic, antihepatotoxic, antiallergic, and hypolipidemic properties (11)(12)(13)(14). Previous study (15) has shown that honey healed chronic wounds and ulcers that had failed to heal under conventional treatment.…”
Section: Introductionmentioning
confidence: 99%