The investigation of biochemical and microbiological properties of four different honey types produced in turkey and the comparison of their effects with silver sulfadiazine on wound healing in a rat model of burn injury

Bulut, Serap Pamak; Gürbüzel, Mihriban; Karabela, SN; Pence, HH; Aksaray, Sebahat; Topal, Uğur

doi:10.4103/njcp.njcp_582_20

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Several natural products such as honey, rosemary and chamomile oils have many health benefits particularly in skin regeneration process. These natural bioactive substances were previously investigated individually as enhancers of wound healing [ 18 , 19 , 20 ]. In our previous study, combination between these materials enhanced the wound healing in equines [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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Skin burns are one of the most difficult medical problems. Recently, studies have been directed towards development of natural products in order to identify effective and safe remedies. In the present study, we evaluated the efficacy of a natural composite (formulated from honey and essential oils) compared with MEBO® (0.25% β-sitosterol) and DERMAZIN® creams (1% silver-sulfadiazine) in the treatment of thermally induced skin burns. For this purpose, four burn-wounds were created on the back of male New Zealand rabbits (n = 10) using a thermal stamp under the effect of general anesthesia. Each wound represents one of the following groups: non-treated, natural composite-cream, MEBO®-cream, and silver-sulfadiazine treated groups, respectively. Treatments were applied once a day topically until one of these wounds appeared to be healed grossly. The non-treated group received no treatment. Grossly, skin burns have been healed after 28 days of the treatment in all groups except of the non-treated group. The healing efficacy of the natural composite, MEBO® and silver-sulfadiazine creams was quite similar macroscopically. However, microscopically, the epidermal layer of the composite-cream treated group was more mature than those of both MEBO® and silver-sulfadiazine creams treated groups. In conclusion, the tested composite may be a promising effective and inexpensive treatment of skin burns.

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Section: Introductionmentioning

confidence: 99%

“…Honey has anti-inflammatory and antibacterial effects which decreasing edema and exudation. Additionally, honey stimulates tissue regeneration which promotes healing and diminishes the scar size [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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Ochratoxin A oral mycotoxin and honey dietary intake effects on TNF-α immunology response, lactic acid bacteria microbial louds, β-glucuronidase enzyme activity, some hematological and biochemical parameters on mice

et al. 2023

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The current study aimed to evaluate ochratoxin A oral mycotoxin and the dietary intake effects of four honey varieties (Nigella sativa, moringa, sidr, and pumpkin–coded as NS, MO, SI, and PU respectively), on the TNF-α immunology response, lactic acid bacteria microbial louds (Lactobacilli and Bifidobacteria), β-glucuronidase enzyme activity, some hematological and biochemical parameters of mice. MO Honey Group + OTA Infection had the highest value of TNF-α immunology response at 445.17 pg/mL. It was followed by PU Honey Group + OTA Infection at 360.88 pg/mL, while NS Honey Group + OTA Infection reported the lowest at 210.03 pg/mL. Honey dietary intake efficiently increased the colonic probiotic bacteria counts Lactobacilli and Bifidobacteria, in the animal’s cecum from 0.93 in SI Honey Group + OTA Infection to 2.59 in MO Honey Group + OTA Infection and from 1.78 in PU Honey Group + OTA Infection to 3.22 in NS Honey Group + OTA Infection Log 10 CFU/g, respectively. The β-glucuronidases enzyme activity in the caecum contents of mice groups ranged from 0.31 μmol/g in PU Honey Group + OTA Infection to 0.36 μmol/g in SI Honey Group + OTA Infection. Positive and negative control mice groups reported 7.22 and 6.98 × 109 L−1; 8.09 and 8.44 × 1012 L−1 for white blood cell and red blood cell counts, respectively. The mean glutathione concentrations were from 3.17 ng/g in MO Honey Group + OTA Infection, to 4.32 ng/g in SI Honey Group + OTA Infection. Catalase activities ranged from 0.99 u/gin MO Honey Group + OTA Infection to 1.08 u/g in the PU Honey Group + OTA Infection. Honey dietary intake decreased malondialdehyde concentrations in infected mice groups and ranged from 3.84 nmol/g in NS Honey Group + OTA Infection to 5.47 nmol/g in MO Honey Group + OTA Infection. NS Honey Group + OTA Infection reported the lowest values for alkaline phosphatase as 70.15 U L−1, glucose as 6.12 mmol L−1, and urea as 4.89 mmol L−1. SI Honey Group + OTA Infection reported the highest values for AP as 75.52 U L−1 and urea as 5.78 mmol L−1. PU Honey Group + OTA Infection reported the lowest value for ALT as 55.47 U L−1 and the highest value for glucose as 7.88 mmol L−1.

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Clinical and Histological Comparison of Healing by Steel Scalpel, Diode Laser, and Radiofrequency in Palatal Wound: An Animal Study

Elemek,

Gelmez,

Hekimoğlu

et al. 2023

Nigerian Journal of Clinical Practice

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Background: Wound healing following periodontal soft tissue procedures can differ owing to different techniques, the feasibility of which can be determined through detailed macroscopic and microscopic observations. Aims: This study aimed to clinically and histologically evaluate palatal wound healing in rats by secondary intention after excision using a steel scalpel, diode laser, and radiofrequency. Materials and Methods: An excision was made in the edentulous anterior maxilla of 42 4-month-old male Wistar rats weighing 289–428 g. Part of the connective tissue was left in the surgical area to observe the dynamics of secondary intention wound healing. Three experimental groups were established: the steel scalpel, an 810-nm diode laser at a power output of 1.5 W in continuous mode, and a monopolar radiofrequency in a fully rectified waveform at 15 W. Clinical and histological analyses were performed on days 2, 4, and 7. Hemostasis, changes in body weight, defect size, epithelial gap, and inflammatory infiltration were evaluated. Results: The epithelial gap closed completely in all groups on day 7. Bleeding occurred significantly more in the scalpel group (P < 0.001). No significant changes were observed in body weight between the groups. Macroscopically, the mean wound area decreased over time in all groups. Wound healing was significantly slower in the laser group on day 2 and in the radiofrequency group on days 4 and 7 (P < 0.001). Microscopically, the laser created the cleanest wound area, with minimal inflammatory infiltration and no thermal injury. More damage occurred in the connective tissue of the radiofrequency group. Wound healing was observed on day 7 in all groups. Conclusions: Palatal wound healing with secondary intention yielded different outcomes in a rat model when different techniques were used. However, almost complete healing was observed in all wounds, which highlights the importance of the soft tissue left in the surgical area. Wound healing in periodontal soft tissue procedures is not compromised by different techniques, as long as the clinician has sufficient knowledge and experience.

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The investigation of biochemical and microbiological properties of four different honey types produced in turkey and the comparison of their effects with silver sulfadiazine on wound healing in a rat model of burn injury

Cited by 4 publications

References 35 publications

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Ochratoxin A oral mycotoxin and honey dietary intake effects on TNF-α immunology response, lactic acid bacteria microbial louds, β-glucuronidase enzyme activity, some hematological and biochemical parameters on mice

Clinical and Histological Comparison of Healing by Steel Scalpel, Diode Laser, and Radiofrequency in Palatal Wound: An Animal Study

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