The Iron Dextran Complex

Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications

“…Elmore reported an early example on dextrancoated ferromagnetic colloid via the precipitation method in 1938 by the first strategy, 47 while Cox et al reported an iron-dextran complex in 1965 prepared by the second strategy. 48 These early investigations provided a solid foundation for the iron oxide contrast agents commercialized later on, as shown in Table I.…”

Loss of Iron-Dextran through Cuprophane Membrane of a Disposable Coil Dialyser

“…There is, however, a large variation in the published figures of the molecular weight of the complex. Ricketts et al [16], using an ultracentrifugation technique, suggested that the molecular weight was more than 150,000. More recently, Marshall and Rutherford [14] demonstrated that in solution iron-dextran particles were roughly spherical and consisted of two distinct parts -an inner electron-dense FeOOH 'core' (diameter 3 nm) and an outer electron-transparent 'shell' com posed of dextran.…”

Measurement of plasma volume by means of59Fe-labelled dextran and Evans blue compared

“…The molecular weight of 59Fe-dextran is uncertain, but is thought to be of the order of 200,000. Ricketts, Cox, Fitzmaurice, and Moss (1965) showed that the Fe-dextran complex of the type used in the present study had a molecular or particle size much greater than that of gamma globulin, and that there was no evidence of a wide distribution of molecular weight. As supplied, about 1% (61 mg/ 100 ml) of the iron was in the free ionic form, or in a weak ferrous dextran complex, the remainder being in a stable ferric dextran complex.…”