The Isolation of Chondrosamine from Gangliosides and from Submaxillary Mucin.

Blix, Gunnar; Svennerholm, Lars; Werner, Ivar; Finsnes, Ernst; Sörensen, Jörgine Stene; Sørensen, Nils Andreas

doi:10.3891/acta.chem.scand.06-0358

Cited by 117 publications

(20 citation statements)

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“…He named this carbohydrate sialic acid after the Greek word for saliva, τo σιαλo v [10]. Sialic acid was obtained in crystalline form from bovine submaxillary mucin in 1954 [11].…”

Section: Historical Aspects Of Glycobiology In the Oral Cavitymentioning

confidence: 99%

Glycan recognition at the saliva – oral microbiome interface

Cross

Rühl

2018

Cellular Immunology

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The mouth is a first critical interface where most potentially harmful substances or pathogens contact the host environment. Adaptive and innate immune defense mechanisms are established there to inactivate or eliminate pathogenic microbes that traverse the oral environment on the way to their target organs and tissues. Protein and glycoprotein components of saliva play a particularly important role in modulating the oral microbiota and helping with the clearance of pathogens. It has long been acknowledged that glycobiological and glycoimmunological aspects play a pivotal role in oral host-microbe, microbe-host, and microbe-microbe interactions in the mouth. In this review, we aim to delineate how glycan-mediated host defense mechanisms in the oral cavity support human health. We will describe the role of glycans attached to large molecular size salivary glycoproteins which act as a first line of primordial host defense in the human mouth. We will further discuss how glycan recognition contributes to both colonization and clearance of oral microbes.

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“…He named this carbohydrate sialic acid after the Greek word for saliva, τo σιαλo v [10]. Sialic acid was obtained in crystalline form from bovine submaxillary mucin in 1954 [11].…”

Section: Historical Aspects Of Glycobiology In the Oral Cavitymentioning

confidence: 99%

Glycan recognition at the saliva – oral microbiome interface

Cross

Rühl

2018

Cellular Immunology

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“…He called these new compounds gangliosides, and their acid component neuraminic acid. [4] The structure of N-acetylneuraminic acid, also known as sialic acid [5] or lactaminic acid, was elucidated by Richard Kuhn in 1962. [6] The first structure elucidation of a ganglioside, GM1 ( Figure 1) was made by Kuhn and Wiegandt in 1963.…”

Section: Historical Introductionmentioning

confidence: 99%

Sphingolipids—Their Metabolic Pathways and the Pathobiochemistry of Neurodegenerative Diseases

Kolter

Sandhoff

1999

Angew. Chem. Int. Ed.

385

268

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“…Interestingly, compound (29), with the glycerol side chain at the C5 position, did not show the NA inhibitory activity up to 100µM. As demonstrated by many X-ray crystallographic structures of NA-inhibitor complexes [59], the binding pocket of the influenza NA is very shallow and dictates that good inhibitors must meet stringent structural requirements.…”

Section: R=(ch 2 ) 3 Nh 3 + CL -mentioning

confidence: 97%

“…Sialic acids were first isolated in the 1930's, in one case from a salivary gland mucin from which the name "sialic acid" was derived. This is a slightly different compound, isolated from a brain ganglioside, containing both an acid and an amine [29]. The general structure of the sialic acids was elucidated in the 1950's.…”

Section: Sialic Acid (Sa)mentioning

confidence: 99%

Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Zhang¹,

2006

MRMC

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Neuraminidase (NA) is the major surface glycoprotein of the influenza virus. It has been considered a suitable target for designing agents against influenza viruses. Rational drug design of NA inhibitors is now in the clinic and is effective for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review a series of neuraminidase inhibitors and the recent progress in this field.

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The Isolation of Chondrosamine from Gangliosides and from Submaxillary Mucin.

Cited by 117 publications

References 0 publications

Glycan recognition at the saliva – oral microbiome interface

Glycan recognition at the saliva – oral microbiome interface

Sphingolipids—Their Metabolic Pathways and the Pathobiochemistry of Neurodegenerative Diseases

Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

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