The haemolytic reagent allowing direct serological detection of Hc homozygous pigs was obtained by the immunization of a Landrace sow. Another monospecific reagent prepared from immune serum of a Miniature pig made possible the evidence for a new factor of the H system -He. This factor is genetically controlled by the d e l e H6e. Its frequency in Miniature pigs was 0.099. The H system with alleles Hi =Ha, H2 = Hb, H3 = H u b , H' = H c d t Hs = H b d , H6 = Hbe and H7= Hcontinues to be a genetically open system.