The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Song, Da; Wang, Deheng; Yang, Qinghu; Yan, Tianyi; Wang, Zhe; Yan, Yan; Zhao, Juan; Xie, Zhen; Liu, Yuchen; Zhang, Ke; Qazi, Talal Jamil; Li, Yanhui; Wu, Yili; Shi, Qing; Lang, Yiran; Zhang, Heao; Huang, Tao; Wang, Chunjian; Quan, Zhenzhen; Qing, Hong

doi:10.1038/s41467-020-16698-4

Cited by 46 publications

(37 citation statements)

References 44 publications

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“…Previous investigations highlighted functional differences between the two hemispheres (29)(30)(31)(32)(33)(34)(35)(36). Motivated by our observed dorsoventral gradient in spatial tuning, we therefore examined potential differences in SI between the left and the right hemisphere.…”

Section: Significancementioning

confidence: 99%

Topographically organized representation of space and context in the medial prefrontal cortex

Sauer

Folschweiller

Bartos

2022

Proc. Natl. Acad. Sci. U.S.A.

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Spatial tuning of neocortical pyramidal cells has been observed in diverse cortical regions and is thought to rely primarily on input from the hippocampal formation. Despite the well-studied hippocampal place code, many properties of the neocortical spatial tuning system are still insufficiently understood. In particular, it has remained unclear how the topography of direct anatomical connections from hippocampus to neocortex affects spatial tuning depth, and whether the dynamics of spatial coding in the hippocampal output region CA1, such as remapping in novel environments, is transmitted to the neocortex. Using mice navigating through virtual environments, we addressed these questions in the mouse medial prefrontal cortex, which receives direct input from the hippocampus. We found a rapidly emerging prefrontal representation of space in the absence of task rules, which discriminates familiar from novel environments and is reinstated upon reexposure to the same familiar environment. Topographical analysis revealed a dorsoventral gradient in the representation of the own position, which runs opposite to the innervation density of hippocampal inputs. Jointly, these results reveal a dynamically emerging and topographically organized prefrontal place code during spontaneous locomotion.

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Section: Significancementioning

confidence: 99%

Topographically organized representation of space and context in the medial prefrontal cortex

Sauer

Folschweiller

Bartos

2022

Proc. Natl. Acad. Sci. U.S.A.

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“…The findings reported in our study may also have implications for regulating neuronal excitability following acute changes in hippocampal firing patterns and activity‐driven NO generation, such as occur during traumatic brain injuries, epileptiform or changes in temporal spiking properties during fundamental computational activities (Ding et al, 2020; Ghotbeddin et al, 2019; Karimi et al, 2020; Martin et al, 2019; Song et al, 2020).…”

Section: Discussionmentioning

confidence: 60%

Nitrergic modulation of neuronal excitability in the mouse hippocampus is mediated via regulation of Kv2 and voltage‐gated sodium channels

Scheiblich

Steinert

2021

Hippocampus

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Regulation of neuronal activity is a necessity for communication and information transmission. Many regulatory processes which have been studied provide a complex picture of how neurons can respond to permanently changing functional requirements. One such activity‐dependent mechanism involves signaling mediated by nitric oxide (NO). Within the brain, NO is generated in response to neuronal NO synthase (nNOS) activation but NO‐dependent pathways regulating neuronal excitability in the hippocampus remain to be fully elucidated. This study was set out to systematically assess the effects of NO on ion channel activities and intrinsic excitabilities of pyramidal neurons within the CA1 region of the mouse hippocampus. We characterized whole‐cell potassium and sodium currents, both involved in action potential (AP) shaping and propagation and determined NO‐mediated changes in excitabilities and AP waveforms. Our data describe a novel signaling by which NO, in a cGMP‐independent manner, suppresses voltage‐gated Kv2 potassium and voltage‐gated sodium channel activities, thereby widening AP waveforms and reducing depolarization‐induced AP firing rates. Our data show that glutathione, which possesses denitrosylating activity, is sufficient to prevent the observed nitrergic effects on potassium and sodium channels, whereas inhibition of cGMP signaling is also sufficient to abolish NO modulation of sodium currents. We propose that NO suppresses both ion channel activities via redox signaling and that an additional cGMP‐mediated component is required to exert effects on sodium currents. Both mechanisms result in a dampened excitability and firing ability providing new data on nitrergic activities in the context of activity‐dependent regulation of neuronal function following nNOS activation.

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“…The mechanisms of differential spatial tuning properties of both mPFCs remain elusive. Activity in the left but not right CA3 has been reported to be required for spatial memory (40), and long-term plasticity of CA3 outputs in CA1 occur only on synapses originating from the left but not right CA3 (41). While these data suggest pronounced lateralization within the hippocampal circuitry, potential hemispheric asymmetries in CA1 output to the neocortex are much less understood.…”

Section: Discussionmentioning

confidence: 97%

Topographically organized representation of space and context in the medial prefrontal cortex

Sauer

Bartos

2021

Preprint

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Spatial tuning of pyramidal cells has been observed in diverse neocortical regions, but a systematic characterization of the properties of spatially tuned neurons across cortical layers and regions is lacking. Using mice navigating through virtual environments, we find topographical organizational principles for the representation of spatial features in the medial prefrontal cortex. We show that spatial tuning emerges across layers with a dorso-ventral gradient in the depth of spatial tuning, which resides in superficial layers. Moreover, the prefrontal cortex shows hemispheric lateralization of spatial tuning such that neurons located in the left hemisphere display more pronounced spatial tuning. During exploration of a novel compared to a familiar context, a different picture emerges. Context discrimination and familiarity detection is higher in superficial compared to deep layers. However, neurons of the right medial prefrontal cortex discriminate more efficiently between contexts than cells in the left hemisphere. Jointly, these results reveal a complex topographic organization of spatial representation and suggest a division of labor among prefrontal layers and subregions in the encoding of spatial position in the current environment and context discrimination.

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The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Cited by 46 publications

References 44 publications

Topographically organized representation of space and context in the medial prefrontal cortex

Topographically organized representation of space and context in the medial prefrontal cortex

Nitrergic modulation of neuronal excitability in the mouse hippocampus is mediated via regulation of Kv2 and voltage‐gated sodium channels

Topographically organized representation of space and context in the medial prefrontal cortex

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