2010
DOI: 10.5551/jat.3228
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The Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and its Soluble Form: Cardiovascular Implications

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Cited by 72 publications
(72 citation statements)
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References 117 publications
(202 reference statements)
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“…Activated LOX-1 initiates various atherogenic reactions, including the adhesion of monocytes to the endothelium and the transformation of macrophages into foam cells 7) , and it has also been suggested to be involved in destabilization and rupture of atherosclerotic plaques. The membrane proximal to the extracellular domain of LOX-1 can be proteolytically cleaved and released in a soluble form, the level of which is considered to reflect the LOX-1 expression 8) . The serum soluble LOX-1 (sLOX-1) levels have been reported to increase in patients with acute coronary syndrome 9) , type 2 diabetes 10) and obesity 11) .…”
Section: Clinical Characteristics Of the Current Smokersmentioning
confidence: 99%
“…Activated LOX-1 initiates various atherogenic reactions, including the adhesion of monocytes to the endothelium and the transformation of macrophages into foam cells 7) , and it has also been suggested to be involved in destabilization and rupture of atherosclerotic plaques. The membrane proximal to the extracellular domain of LOX-1 can be proteolytically cleaved and released in a soluble form, the level of which is considered to reflect the LOX-1 expression 8) . The serum soluble LOX-1 (sLOX-1) levels have been reported to increase in patients with acute coronary syndrome 9) , type 2 diabetes 10) and obesity 11) .…”
Section: Clinical Characteristics Of the Current Smokersmentioning
confidence: 99%
“…The extracellular domain can be cleaved proteolytically and released as a soluble form (sLOX-1). An elevated circulating level of sLOX-1 may reflect increases in LOX-1 receptor expression, inflammation, and metabolic disorder [15][16][17]. sLOX-1 is elevated in the plasma of individuals with obesity [18] and diabetic mellitus [19], which are characterized as medical conditions of metabolic syndrome.…”
mentioning
confidence: 99%
“…ROS have multiple effects on cell function depending on the amount and subcellular location of ROS generated. The cause of increased ROS in this setting is not known, but may relate to increased production of ROS due to increased metabolic activity, stimulated production by mechanical strain, neurohormonal activation, inflammatory cytokines, and decreased antioxidant activity [43][44][45][46][47] . Controlled intracellular ROS production from NADPH oxidase has been shown to be necessary for normal cellular development and function, whereas excessive ROS generation is implicated in myocardial hypertrophy and heart failure 48) .…”
Section: Discussionmentioning
confidence: 99%