The link between atopic dermatitis and asthma- immunological imbalance and beyond

Yaneva, Martina; Darlenski, Razvigor

doi:10.1186/s40733-021-00082-0

Cited by 32 publications

(26 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 55% of our patients with severe AD had asthma, compared to 33% with mild disease. Studies have proposed Th2‐shifted systemic inflammation as a factor for development of multiple atopic comorbidities in severe AD 33,34 . There have been reports that link the pronounced immunologic Th2‐shift of asthma directly with epidermal skin barrier effects, causing susceptibility to more severe AD, skin infections and microbiome changes 35 .…”

Section: Discussionmentioning

confidence: 99%

Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study

Salava

Salo

Leppänen

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Severity‐associated factors in atopic dermatitis (AD) have focussed on early onset, concomitant atopic diseases, markers of Th2‐shifted inflammation and filaggrin mutations. Objectives To investigate factors associated with severe AD in Finnish patients. Methods We conducted a single‐centre, cross‐sectional observational study with 502 AD patients aged 4.79 to 79.90 years (mean 32.08 years). Disease severity was assessed with the Rajka–Langeland severity score and EASI and associated clinical signs were evaluated. Data regarding onset, relatives, atopic and other comorbidities was gathered retrospectively. We investigated total serum IgE‐levels, a panel of filaggrin null mutations and functional variants of genes associated with skin barrier defects. Results Factors more frequent in severe AD included early onset (P = 0.004, 95%CI 0.000–0.024), male sex (P = 0.002, 95%CI 0.000–0.11), history of smoking (P = 0.012, 95%CI 0.000–0.024), concomitant asthma (P = 0.001, 95%CI 0.000–0.011), palmar hyperlinearity (P = 0.013, 95%CI 0.014–0.059), hand dermatitis (P = 0.020, 95%CI 0.000–0.029) and history of contact allergy (P = 0.042, 95%CI 0.037–0.096). Body mass indices (P < 0.000, 95%CI 0.000–0.011) and total serum IgE‐levels (P < 0.000, 95%CI 0.000–0.011) were higher in severe AD. No differences were observed for allergic rhinitis, allergic conjunctivitis, food allergy, peanut allergy, prick positivity, keratosis pilaris, history of herpes simplex infections, filaggrin null mutations and other gene variants. Conclusions Severity determinants in Finnish patients seem to be early‐onset, male sex, smoking, overweight, concomitant asthma, palmar hyperlinearity, hand dermatitis and high IgE‐levels. A sub‐typing of patients in relation to confirmed severity determinants may be useful for course prediction, prognosis and targeted AD management.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study

Salava

Salo

Leppänen

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Fig. 22); these 3 groups represent biologically more similar subtypes of autoimmune diseases 50 , suggesting that can differentiate between subgroups of diseases from the same category.…”

Section: Resultsmentioning

confidence: 98%

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Zhang

Hou

Dey

et al. 2021

Preprint

View full text Add to dashboard Cite

Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we introduce single-cell Disease Relevance Score (scDRS), an approach that links scRNA-seq with polygenic risk of disease at individual cell resolution; scDRS identifies individual cells that show excess expression levels for genes in a disease-specific gene set constructed from GWAS data. We determined via simulations that scDRS is well-calibrated and powerful in identifying individual cells associated to disease. We applied scDRS to GWAS data from 74 diseases and complex traits (average N=341K) in conjunction with 16 scRNA-seq data sets spanning 1.3 million cells from 31 tissues and organs. At the cell type level, scDRS broadly recapitulated known links between classical cell types and disease, and also produced novel biologically plausible findings. At the individual cell level, scDRS identified subpopulations of disease-associated cells that are not captured by existing cell type labels, including subpopulations of CD4+ T cells associated with inflammatory bowel disease, partially characterized by their effector-like states; subpopulations of hippocampal CA1 pyramidal neurons associated with schizophrenia, partially characterized by their spatial location at the proximal part of the hippocampal CA1 region; and subpopulations of hepatocytes associated with triglyceride levels, partially characterized by their higher ploidy levels. At the gene level, we determined that genes whose expression across individual cells was correlated with the scDRS score (thus reflecting co-expression with GWAS disease genes) were strongly enriched for gold-standard drug target and Mendelian disease genes.

show abstract

“…Moreover, atopic dermatitis is associated with food allergy and allergic rhinitis. Studies confirm a higher prevalence of asthma in patients with atopic dermatitis [ 34 ].…”

Section: Discussionmentioning

confidence: 95%

“…The findings of our study indicate that house dust allergy, hay fever, and atopic dermatitis increase the risk of asthma. Atopic dermatitis is often one of the first stages of the allergic march that can lead to the development of asthma [ 34 ]. Moreover, atopic dermatitis is associated with food allergy and allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma

Wypych-Ślusarska

Grot

Maria

et al. 2022

IJERPH

View full text Add to dashboard Cite

Background: Epidemiological data concerning the level of asthma morbidity indicate that in Poland, asthma is diagnosed in 5–10% of the pediatric population. Aim The purpose of this study was to compare the prevalence of respiratory symptoms and allergies in a group of children with and without asthma and to evaluate the association between exposure to environmental factors and the prevalence of bronchial asthma in a pediatric population. Material and Methods: A cross-sectional study was conducted on a group of 995 children attending primary schools in the province of Silesia in 2018–2019. The research tool was an anonymous questionnaire developed based on the form used in The International Study of Asthma and Allergies in Childhood (ISAAC). Children’s health status, the prevalence of bronchial asthma, and the performance of allergic skin tests were assessed based on parents’ indications in a questionnaire. Environmental exposures such as mold and dampness in apartments or ETS were similarly assessed. Analyses were performed using Statistica 13.0; p < 0.05. Results: A total of 88 subjects (8.8%) suffered from bronchial asthma. Parents of children with asthma, compared to parents of children without the disease, were more likely to rate their children’s health as rather good (43.2% vs. 38.0%) or average (21.6% vs. 3.1%). All analyzed respiratory symptoms, as well as allergies, were statistically more frequent in children with bronchial asthma. Conclusions: The parent’s subjective assessment of the child’s health varied significantly according to the asthma diagnosis. Asthma is also associated with other diseases: allergic reactions to pollen, house dust, hay fever, and AD (atopic dermatitis) were statistically significantly more frequent among children diagnosed with bronchial asthma.

show abstract

The link between atopic dermatitis and asthma- immunological imbalance and beyond

Cited by 32 publications

References 83 publications

Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study

Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma

Contact Info

Product

Resources

About