The Lipid Composition of Serum in Patients With Liver Disease*

Phillips, Gerald B.

doi:10.1172/jci104187

Cited by 106 publications

(28 citation statements)

References 37 publications

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“…Serum lecithin accumulates in patients with various types of liver disease but this accumulation is least in patients with far advanced cirrhosis (48)(49)(50). The per cent lecithin in the serum of patients with target cells reported herein was not significantly different from normal, and in patients with spur cells it was less than normal.…”

Section: Discussionmentioning

confidence: 49%

An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver Disease

Cooper¹,

Diloy-Puray²,

Lando³

et al. 1972

J. Clin. Invest.

190

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A B S T R A C T MNlost p)atiellts witlh stable cirrhosis of the alcoholic have "target" red cells; however, a minoritv have "spur" cells and severe hemolytic anemia. These two syndromes were studied in 27 patients with target cells and 17 patients with spur cells, all of whom had advanced cirrhosis. The cholesterol and phospholipi(d content of red cell membranes effectively distinguished target cells from spur cells. Target cells alone were rich in lecithin, and both the cholesterol/phospholipid and cholesterol/lecithin mole ratios were greater in spur cells. The cholesterol/phospholipid mole ratio of both types of red cells correlated closely with the free cholesterol saturation of serum lipoproteins, as defined by the anmount of free clholesterol relative to phospholipid and protein in these lipoproteins. Lecithin: cholesterol acyltransferase (LCAT) activity was decreased in most patients with target cells and spur cells; however, the relationship between this activity and the lipid abnormiialities observed was weak. Serum bile acid levels also correlated poorly witlh serum and cell lipids. However, in patients with target cells the amount of cholic and (leoxycholic acids in serumi was approximately equal to the amount of chenodeoxycholic acid, whereas in patients with spur cells chenodeoxycholic acid (the precursor of lithocholic acid) pre(lominatedl.

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Section: Discussionmentioning

confidence: 49%

An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver Disease

Cooper¹,

Diloy-Puray²,

Lando³

et al. 1972

J. Clin. Invest.

190

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“…This has also been found true for patients with liver disease. 29 The values for phospholipids in pooled lipid extracts ( fig. 2) of serum and synovial fluid determined by combined silicic acid column and paper chromatography differ slightly from those discussed above.…”

Section: Discussionmentioning

confidence: 99%

Synovial fluid lipids in normal individuals and patients with rheumatoid arthritis

Bole

Peltier

1962

Arthritis & Rheumatism

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Normal human synovial fluid contains trace amounts of phospholipids and cholesterol. Phospholipid composition is similar to that in serum. Rheumatoid synovial fluid contains increased amounts of phospholipid, cholesterol, and neutral lipids. I n most cases the concentration is 40 to 60 per cent of that found in simultaneously collected serum specimens. A direct relationship appears to exist between total synovial fluid protein and lipid concentration. No relationship could be established between lipid content in rheumatoid synovial fluid, and totaI cell content, hyaluronic acid, severity or duration of synovitis in the involved joint.Normal liquido synovial in humanos contine quantitates tracia de phospholipidos e de cholesterol. Iste phospholipidos es simile in composition a illos del sero. Le liquido synovial ab patientes rheumatoide contine augmentate quantitates de phospholipido, de cholesterol, e de lipidos neutre. In le majoritate del casos, le concentration es 40 a 60 pro cento de ill0 trovate in simultaneemente colligite specimens de sero. Un relation directe pare exister inter le proteina total e le concentration lipidic in le liquido synovial. Nulle relation poteva esser establite inter le contento de lipidos in liquido synovial ab patientes rheumatoide e le parametros del total contento cellular, de acido hyaluronic, e del severitate o del duration de synovitis in le afficite articulation.NTEREST in further studies on the lipids of rheumatoid synovial fluid I was prompted by increasing evidence that a variety of cells synthesize both neutral lipids and phospholipids. Of considerable importance is the suggestion that several types of cells can contribute to extracellular lipid concentration. Recent investigations by Buchanan,l and Marks2 have shown that leukocytes possess this capacity. Preliminary reports by Jackson3 indicate the cells of the carrageenin granuloma synthesize lipids, and studies in this laboratory4 indicate that the cells of the polyvinyl granuloma will incorporate glycerol-C14 into phospholipids and neutral lipids. By comparing the lipid composition of serum with that of the cells, and the cell poor fraction of synovial fluid, it was hoped that additional information as to the source of these lipids might be obtained.Over a century ago Frerichs5 reported that traces of fat were present in bovine synovial fluid. Ropes and Bauers found no lipid in bovine fluid, but did report the presence of cholesterol in rheumatoid joint fluid. It was their impressicn that synovial lipids accumulated in joints where excessive tissue destruction had occurred. This observation was in agreement with earlier work by

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“…Paper electrophoresis was performed according to the method of Lees and Hatch (43). Electrophoresis of lipoprotein fractions was carried out also in 1% agar and 1%o agarose gels by the method of Grabar and Williams (40) (13,14,26). The qualitative and quantitative changes in the lipoprotein patterns of patients with obstructive jaundice were studied utilizing the fractionation procedure ( obtained from patients with obstructive jaundice by standard sequential preparative ultracentrifugation showed that VLDL consisted of LP-A and LP-B (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Flint (2) observed, more than a century ago, an increased blood cholesterol concentration in patients with obstructive jaundice. Subsequent studies correlating plasma lipids with various liver diseases (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) demonstrated dramatic changes in plassma lipids and lipoproteins in patients with intraor extrahepatic biliary obstruction.…”

mentioning

confidence: 99%

A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects

Seidel¹,

Alaupovic²,

Furman³

1969

J. Clin. Invest.

324

123

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The Lipid Composition of Serum in Patients With Liver Disease*

Cited by 106 publications

References 37 publications

An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver Disease

An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver Disease

Synovial fluid lipids in normal individuals and patients with rheumatoid arthritis

A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects

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