The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer

Pan, Zhiwen; Mao, Weimin; Bao, Yi Wang; Zhang, Min; Su, Xinhua; Xu, Xiaohong

doi:10.1002/cam4.770

Cited by 84 publications

(87 citation statements)

References 19 publications

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“…EC is one of the most common types of cancer accompanied by poor prognosis, and the poor outcomes in EC patients are related to diagnosis at advanced stages and the tendency for metastases (Liu et al ., ). lncRNAs and miRNAs have been revealed to have the potential to function in the initiation and progression of EC (Pan et al ., ; Qi et al ., ). The present study explored the mechanism of how lncRNA PVT1 and miR‐145 function in EC cells.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Shen

Liu

et al. 2019

Molecular Oncology

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Accumulating evidence has established that long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) is a tumor regulator in many cancers. Here, we aimed to investigate the possible function of lncRNA PVT1 in esophageal carcinoma (EC) via targeting of microRNA‐145 (miR‐145). Initially, microarray‐based gene expression profiling of EC was employed to identify differentially expressed genes. Moreover, the expression of lncRNA PVT1 was examined and the cell line presenting with the highest level of lncRNA PVT1 expression was selected for subsequent experiments. We then proceeded to examine interaction among lncRNA PVT1, FSCN1, and miR‐145. The effect of lncRNA PVT1 on viability, migration, invasion, apoptosis, and tumorigenesis of transfected cells was examined with gain‐of‐function and loss‐of‐function experiments. We observed that lncRNA PVT1 was robustly induced in EC. lncRNA PVT1 could bind to miR‐145 and regulate its expression, and FSCN1 is a target gene of miR‐145. Overexpression of miR‐145 or silencing of lncRNA PVT1 was revealed to suppress cell viability, migration, and invasion abilities, while also stimulating cell apoptosis. Furthermore, our in vivo results showed that overexpression of miR‐145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. In conclusion, our research reveals that down‐regulation of lncRNA PVT1 could potentially promote expression of miR‐145 to repress cell migration and invasion, and promote cell apoptosis through the inhibition of FSCN1. This highlights the potential of lncRNA PVT1 as a therapeutic target for EC treatment.

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Section: Discussionmentioning

confidence: 99%

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Shen

Liu

et al. 2019

Molecular Oncology

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“…Increased LINC00152 could promote cancer cell proliferation, invasion, and metastasis. Moreover, a recent study showed that CASC9 expression is upregulated and regulates cell migration and invasion in esophageal cancer . We designed siRNAs for LINC00152 and CASC9 and transfected them into SW1990 or BxPC‐3 cells.…”

Section: Resultsmentioning

confidence: 99%

Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma

Yuan

Sui

et al. 2017

Cancer Medicine

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies with the worst prognosis. Recent studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. However, the expression pattern and roles of lncRNAs in the development of PDAC remain unknown. Herein, we globally analyzed the lncRNA expression profile in human PDAC and non‐tumor tissues using four independent public microarray datasets from Gene Expression Omnibus (GEO). The analysis of GEO datasets by repurposing microarray probes confirmed that hundreds of lncRNAs are differentially expressed in PDAC tissues compared with normal tissues. We selected four lncRNAs including LINC00152, CASC9, LINC00226 and F11‐AS1 for validation in PDAC cell lines and normal cells. Loss of function assays were performed to investigate the roles of LINC00152 and CASC9 in PDAC cell proliferation and invasion. Taken together, our findings demonstrate lncRNA expression alterations in PDAC and may provide new potential molecular markers for PDAC patient diagnosis and treatment.

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“…However, it is not clear whether this study analyzed ESCC or EAC samples, although levels of MALAT1 correlated with lymphatic invasion, distant metastasis, and tumor differentiation. In another report, RNA sequence analyses revealed that the lncRNA CASC9 was upregulated in ESCC 50 . Knockdown of CASC9 in ESCC cells reduced their migration and invasion.…”

Section: Lncrnas In Be and Eacmentioning

confidence: 92%

Long Noncoding RNAs in the Pathogenesis of Barrett’s Esophagus and Esophageal Carcinoma

Abraham

Meltzer

2017

Gastroenterology

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For many years, only a small fraction of the human genome was believed to regulate cell function and development. This protein-coding portion composed only 1% to 2% of 3 billion human DNA base pairs— the remaining sequence was classified as junk DNA. Subsequent research has revealed that most of the genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20–23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides). These noncoding RNA classes have been shown to use diverse molecular mechanisms to control gene expression and organ system development. As anticipated, alterations in this large control system can contribute to disease pathogenesis and carcinogenesis. We review the involvement of noncoding RNAs—lncRNAs in particular—in development of Barrett's esophagus and esophageal carcinoma.

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The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer

Cited by 84 publications

References 19 publications

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Retracted: Down‐regulation of long noncoding RNA PVT1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via microRNA‐145‐mediated inhibition of FSCN1

Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma

Long Noncoding RNAs in the Pathogenesis of Barrett’s Esophagus and Esophageal Carcinoma

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