The Main Cytotoxic Effects of Methylseleninic Acid on Various Cancer Cells

Varlamova, Elena G.; Turovsky, Egor A.

doi:10.3390/ijms22126614

Cited by 36 publications

(43 citation statements)

References 112 publications

(161 reference statements)

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“…Selenite-induced cell death is independent of these death proteases [17,[29][30][31]. On the other hand, the anti-carcinogenic effects of Se mediated byCH 3 SeH or its derivatives have been shown in the papers by References [32][33][34][35][36][37][38]. They have shown that the CH 3 SeH-precusor MSeCN and MSeC can inhibit mammary cell growth, arresting cells in G1 phase and inducing apoptosis [21,22,30,[39][40][41][42].…”

Section: Metabolism Of Selenium Compoundsmentioning

confidence: 99%

Antitumor Effects of Selenium

Kim¹,

Choi

Park

et al. 2021

IJMS

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Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites. Hydrogen selenide from selenite, and methylselenol (MSeH) from Se-methylselenocyteine (MSeC) and methylseleninicacid (MSeA) are the most reactive metabolites produced reactive oxygen species (ROS); furthermore, these metabolites may involve in oxidizing sulfhydryl groups, including glutathione. Selenite also reacted with glutathione and produces hydrogen selenide via selenodiglutathione (SeDG), which induces cytotoxicity as cell apoptosis, ROS production, DNA damage, and adenosine-methionine methylation in the cellular nucleus. However, a more pronounced effect was shown in the subsequent treatment of sodium selenite with chemotherapy and radiation therapy. High doses of sodium selenite were effective to increase radiation therapy and chemotherapy, and further to reduce radiation side effects and drug resistance. In our study, advanced cancer patients can tolerate until 5000 μg of sodium selenite in combination with radiation and chemotherapy since the half-life of sodium selenite may be relatively short, and, further, selenium may accumulates more in cancer cells than that of normal cells, which may be toxic to the cancer cells. Further clinical studies of high amount sodium selenite are required to treat advanced cancer patients.

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Section: Metabolism Of Selenium Compoundsmentioning

confidence: 99%

Antitumor Effects of Selenium

Kim¹,

Choi

Park

et al. 2021

IJMS

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“…It has been shown that Se dioxide can prevent the oxidative damage of DNA caused by the interaction of Fe (II), Cr (III) and Cu (II) with hydrogen peroxide by forming a coordination complex with metals [ 4 , 5 ]. Among all known organic Se-containing compounds, a special place is occupied by methylseleninic acid (MSA), which is formed as a result of the oxidative decomposition of methyl selenocysteine and has a number of important advantages over other selenium agents [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Varlamova

Turovsky

Блинова

2021

IJMS

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This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review.

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“…Recently, more and more works have appeared on the study of the anticancer effect of selenium, selenoproteins, and SeNP [ 32 , 33 , 34 ]. The anticancerous property of SeNP is due to the induction of glutathione S-transferase (GST) by selenium [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Ca2+-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels

Turovsky

Varlamova

2021

Biology

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To date, there are practically no data on the mechanisms of the selenium nanoparticles action on calcium homeostasis, intracellular signaling in cancer cells, and on the relationship of signaling pathways activated by an increase in Ca2+ in the cytosol with the induction of apoptosis, which is of great importance. The study of these mechanisms is important for understanding the cytotoxic effect of selenium nanoparticles and the role of this microelement in the regulation of carcinogenesis. The work is devoted to the study of the role of selenium nanoparticles obtained by laser ablation in the activation of the calcium signaling system and the induction of apoptosis in human glioblastoma cells (A-172 cell line). In this work, it was shown for the first time that the generation of Ca2+ signals in A-172 cells occurs in response to the application of various concentrations of selenium nanoparticles. The intracellular mechanism responsible for the generation of these Ca2+ signals has also been established. It was found that nanoparticles promote the mobilization of Ca2+ ions from the endoplasmic reticulum through the IP3-receptor. This leads to the activation of vesicular release of ATP through connexin hemichannels (Cx43) and paracrine cell activation through purinergic receptors (mainly P2Y). In addition, it was shown that the activation of this signaling pathway is accompanied by an increase in the expression of pro-apoptotic genes and the induction of apoptosis. For the first time, the role of Cx43 in the regulation of apoptosis caused by selenium nanoparticles in glioblastoma cells has been shown. It was found that inhibition of Cx43 leads to a significant suppression of the induction of apoptosis in these cells after 24 h treatment of cells with selenium nanoparticles at a concentration of 5 µg/mL.

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The Main Cytotoxic Effects of Methylseleninic Acid on Various Cancer Cells

Cited by 36 publications

References 112 publications

Antitumor Effects of Selenium

Antitumor Effects of Selenium

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Mechanism of Ca2+-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels

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