2016
DOI: 10.1136/heartjnl-2016-310607
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The management of the third stage of labour in women with heart disease

Abstract: The use of an additional 2 U of oxytocin for the management of third stage in women with HD had no cardiac consequences and was associated with a significantly lower blood loss. Further larger studies on a larger population of women with HD are needed.

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Cited by 28 publications
(13 citation statements)
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“…The third stage of labour is usually facilitated by the administration of syntometrine, which causes uterine contractions and minimises post-partum haemorrhage. However, this drug also has a pronounced hypertensive and vasoconstrictive effect and so is avoided in most women with heart disease in favour of a slow infusion of syntocinon (an oxytocin analogue) [ 82 ]. Misoprostol may be used for post-partum haemorrhage, with syntometrine reserved only for severe maternal haemorrhage where the benefit outweighs the risk [ 82 ].…”
Section: Pregnancy and Pre-deliverymentioning
confidence: 99%
“…The third stage of labour is usually facilitated by the administration of syntometrine, which causes uterine contractions and minimises post-partum haemorrhage. However, this drug also has a pronounced hypertensive and vasoconstrictive effect and so is avoided in most women with heart disease in favour of a slow infusion of syntocinon (an oxytocin analogue) [ 82 ]. Misoprostol may be used for post-partum haemorrhage, with syntometrine reserved only for severe maternal haemorrhage where the benefit outweighs the risk [ 82 ].…”
Section: Pregnancy and Pre-deliverymentioning
confidence: 99%
“…This is probably due to the cautious use of uterotonics as suggested by current guidelines, which advise the use of 2 IU of oxytocin due to its negative inotropic and positive chronotropic effects. This advice is supported by a recent study on the impact of a 2‐unit infusion of oxytocin given over 10 minutes in addition to a standard low dose infusion; women receiving the additional 2 IU infusion had a lower estimated blood loss at delivery (849 versus 505 ml) . There was no evidence of arrhythmia, ST segment change or alteration in maternal haemodynamics (blood pressure, heart rate, mean arterial blood pressure).…”
Section: Third Stage Of Labour and Antibiotic Prophylaxismentioning
confidence: 76%
“…The third stage of labour is usually facilitated by the administration of syntometrine, which causes uterine contractions and minimizes post-partum haemorrhage. However, this drug also has a pronounced hypertensive and vasoconstrictive effect and so is avoided in most women with heart disease in favour of a slow infusion of syntocinon (an oxytocin analogue) (Cauldwell et al, 2017).…”
Section: Discussionmentioning
confidence: 99%