The purpose of this study is to analyze the meaning of nasyiyah in the interpretation of Salman from a neo-science perspective. The development of neuroscience and Islamic education in this modern era is in line with the emergence of new findings, namely research about the meaning (nasyiyah) in the Qur'an which some commentators define as "the crown" (prefrontal cortex). This research data is sourced through literature observations related to scientific journal descriptions as well as scrutiny of references to research works, both manually and digitally, which focus on discussing the meaning of nasyiyah in Surah Al-Alaq verses 15-16. This research is a literature study with a qualitative method. Research results prove that the meaning of nasyiyah is identical to the meaning (forehead). In Salman's interpretation, what is meant by the crown is the brain, especially the prefrontal cortex. From a neuroscience perspective, this section plays an important role in controlling emotions as an alternative and healthy memory in the long term, which affects the pattern of thought. Giving a picture of the minds of people who believe and those who turn away from their god, has broad implications for the development of Islamic education today.