The mass balance model perfectly fits both Hall et al. underfeeding data and Horton et al. overfeeding data

Abstract

Background & Aims Recently, the validity of mass balance model (MBM) was questioned based on two feeding studies. Thus, we simulated both of these feeding trials. Methods MBM describes the temporal evolution of body weight and body composition under a wide variety of feeding experiments. This computational study simulated, utilizing MBM, the underfeeding trial by Hall et al. (Cell Metab. 2015;22:427-36) and the overfeeding trial by Horton et al. (Am J Clin Nutr. 1995;62:19-29). Results Our simulation results indicate that data from both of these feeding trials perfectly match MBM-based predictions, i.e., MBM gives a remarkably accurate description of experimental data. Conclusions It is becoming increasingly clear that our model (MBM) is perfectly able to predict body weight and body composition fluctuations under a wide variety of feeding experiments.

A reanalysis of the highly important metabolic ward feeding data of Hall and colleagues: a brief report

“…B1. Fat loss trajectories that underlay weight loss in A1 perfectly match those reported by Hall et al [3] over the trial duration (6 days). B2.…”

“…A growing body of evidence indicate that the widely accepted EBT ("Calories In, Calories Out) is a flawed paradigm. Instead, it is becoming increasingly clear that body mass is regulated according to the "Mass In, Mass Out" principle [2,3,4,5,6,9]. A very comprehensive and detailed review can be found in source [9], while a relatively easy-to-read and practical review can be found in [5].…”

Chronic Positive Mass Balance is the Actual Etiology of Obesity: Time for A Paradigm Shift?

“…For further details, please see, including Supplementary Files, [1], [2] and [3]. Please note that only the most important references are listed for this article, as the others can be found in the aforementioned papers.…”

“…A highly significant practical application of a mass balance approach is that a low-carbohydrate/high-fat diet leads to a greater body mass and fat mass loss than an isocaloric high-carbohydrate/low-fat diet because it provides less nutrient mass [1,2,3]. When the energy fraction from dietary fat increases, while energy intake is clamped (i.e., fixed), mass intake decreases due to the significantly higher energy density of fat compared with other energy substrates.…”

“…It is possible for an open system, such as the human body, to be at mass balance while the system experiences a persistent energy imbalance. That is, energy balance may be positive (ΔE > 0) or negative (ΔE < 0) yet the mass change that may occur during energy flux is not required by the Law of Conservation of Energy (i.e., the First Law of Thermodynamics) to mirror the energy balance direction [1,2,3].…”