The Maternal Lifestyle Study: Effects of Substance Exposure During Pregnancy on Neurodevelopmental Outcome in 1-Month-Old Infants

Lester, Barry M.; Tronick, Edward Z.; LaGasse, Linda L.; Seifer, Ronald; Bauer, Charles R.; Shankaran, Seetha; Bada, Henrietta S.; Wright, Linda L.; Smeriglio, Vincent L.; Lu, Jing; Finnegan, Loretta P.; Maza, Penelope L.

doi:10.1542/peds.110.6.1182

Cited by 288 publications

(309 citation statements)

References 60 publications

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“…These subtle neurobehavioral findings are consistent with previous findings in cocaine [30]and nicotine [27]-exposed children and suggest potential MA-induced neurotoxic effects. Also consistent with previous findings in cocaine exposed children, there are no identifiable patterns of neurobehavior that are consistent with a methamphetamine exposure "syndrome".…”

Section: Discussionsupporting

confidence: 90%

“…Further, MA using mothers were greater than 4 times more likely to be heavy users of these substances than mothers in the comparison group (Table 1). These findings are similar to those in previous studies addressing maternal substance use [30]. Although amphetamines and ecstasy using mothers were included in the MA group, a small percentage (<1%) reported using during pregnancy.…”

Section: Maternal Drug Usesupporting

confidence: 89%

“…Covariates were selected based on conceptual reasons, published literature, and characteristics from Tables 1 and 2 that differed between groups if not highly correlated with other covariates. The effect of prenatal exposures to alcohol, tobacco, and marijuana on NNNS measures have been previously reported [27], as have birth weight effects [30].…”

Section: Standard Covariate Setmentioning

confidence: 82%

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Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

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164

127

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Background-Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown.Objective-To examine the neurobehavioral effects of prenatal MA exposure.Design-The Infant Development, Environment and Lifestyle (IDEAL) study screened 13,808 subjects and 1632 were eligible and consented. 166 (n=74 exposed) were enrolled in a longitudinal follow up. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. The NICU Network Neurobehavioral Scale (NNNS) was administered within the first 5 days of life. Analyses conducted on NNNS summary scores included exposure group effects, heavy MA use effects, association with frequency of use by trimester, and dose-response relationships with amphetamine metabolites.Results-After adjusting for covariates, exposure to MA was associated with increased physiological stress. Heavy MA use was related to lower arousal, more lethargy, and increased physiological stress. First trimester MA use was related to elevated physiological stress. Third trimester use was related to poorer quality of movement. Higher level of amphetamine metabolites in meconium was associated with increased CNS stress.Conclusions-Prenatal MA exposure was associated with neurobehavioral patterns of decreased arousal, increased stress, and poor quality of movement. The dose response relationships may represent neurotoxic effects from MA.

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Section: Discussionsupporting

confidence: 90%

Section: Maternal Drug Usesupporting

confidence: 89%

Section: Standard Covariate Setmentioning

confidence: 82%

See 1 more Smart Citation

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

Self Cite

164

127

View full text Add to dashboard Cite

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“…1 Also, sensitive neurobehavioral instruments have established the negative effects of intra-uterine exposure to marijuana. 2,3 Moreover, there are negative economic and social impacts which are well documented for both drugs. 4 There are few studies made in Brazil on this subject [5][6][7] and only one used hair test to detect drug use.…”

Section: Introductionmentioning

confidence: 99%

Correlates of substance use during adolescent pregnancy in São Paulo, Brazil

Bessa

Mitsuhiro

Chalem

et al. 2010

Rev. Bras. Psiquiatr.

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Objective: To investigate the association of cocaine and marijuana use during adolescent pregnancy in São Paulo-SP, Brazil, with psychiatric disorders, social status and sexual history. Method: One thousand pregnant adolescents were assessed by using the Composite International Diagnostic Interview, and sociodemographic and socio-economic questionnaire at the obstetric center of a public hospital in São Paulo. Hair samples were collected for analysis. Results: The following data were associated with cocaine and/or marijuana use during the third trimester of the pregnancy: being younger than 14 years of age, having a history of more than 3 sexual partners, and having psychiatric disorders, specifically, bipolar disorder, post-traumatic stress disorder, and somatoform disorder. Conclusion: In early adolescence pregnancy, having 3 or more sexual partners in life for this population is significantly associated with the use of cocaine or marijuana during gestation. This association suggests that specific intervention programs should target these young women. Descriptors

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“…Much of the literature on drug-exposed children focuses on the effects of prenatal cocaine or opiate exposure (Barth & Needell, 1996;Lester et al, 2002;Lester et al, 2003;Lester, Andreozzi, & Appiah, 2004). However, some studies have assessed the effects of methamphetamine-exposed infants compared with non-methamphetamine exposed infants in utero.…”

Section: Exposure To Methamphetamine Manufacturementioning

confidence: 99%