The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging

Egbert, Megan; Ruetze, M.; Sattler, Martin; Wenck, Horst; Gallinat, Stefan; Lucius, Ralph; Weise, Julia M.

doi:10.1016/j.jdermsci.2013.08.010

Cited by 69 publications

(52 citation statements)

References 44 publications

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“…Human skin is continuously exposed to environmental influences and is therefore subjected to both intrinsic and extrinsic aging processes [2]. Intrinsic aging of skin is a natural consequence of physiological change and extrinsic factors, such as, ultraviolet (UV) exposure, environment pollution, and nicotine.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, acute exposure of skin to UV light causes sunburn, inflammation, immune suppression, and dermal connective tissue damage [3], whereas chronic UV exposure over many years disrupts the normal skin architecture and ultimately causes photoaging and even skin cancer [4]. Wrinkle formation is representative of skin aging and is characterized by reduced skin elasticity and degeneration of the extracellular matrix (ECM), which in the dermis is produced by fibroblasts and is composed of a mesh of fibrous proteins, such as, collagen and elastic fibers, and glycosaminoglycans that influence the outer appearance of skin [2].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Wrinkle Effect of Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-kB Signaling

Jung

Kim

et al. 2014

PLoS ONE

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Skin is in direct contact with the environment and therefore undergoes aging as a consequence of environmentally induce damage. Wrinkle formation is a striking feature of intrinsic and photo-induced skin aging, which are both associated with oxidative stress and inflammatory response. The present study was undertaken to identify the mechanisms responsible for the anti-wrinkle effects of MLB, and thus, we investigated whether magnesium lithospermate B (MLB) from Salvia miltiorrhiza BUNGE associated with wrinkle formation caused by intrinsic and extrinsic skin aging using Sprague-Dawley rats aged 5 and 20 months and ultraviolet B (UVB)-irradiated human skin fibroblasts cells, respectively. The results obtained showed that the oral administration of MLB significantly upregulated the level of type I procollagen and downregulated the activities and expressions of matrix-metalloproteinases (MMPs) in rat skin. In fibroblasts, MLB suppressed the transactivation of nuclear factor-kB (NF-kB) and activator protein 1(AP-1), which are the two transcription factors responsible for MMP expression, by suppressing oxidative stress and the mitogen activated protein kinase (MAPK) pathway. Our results show that the antioxidant effect of MLB is due to the direct scavenging of reactive oxygen species (ROS) and its inhibitory effects on NF-kB-dependent inflammation genes, such as, cyclooxygenase-2 and inducible nitric oxide synthase. MLB was found to reverse both age- and UVB-related reductions in skin procollagen levels by suppressing the expressions and activities of NF-kB and AP-1-dependent MMPs by modulating ROS generation and the MAPK signaling pathway. We suggest that MLB potentially has anti-wrinkle and anti-skin aging effects.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Wrinkle Effect of Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-kB Signaling

Jung

Kim

et al. 2014

PLoS ONE

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“…Moreover, it is a visible organ that allows assessment of the health and well-being of an individual and reflects many aesthetic parameters [1][2][3]. Similar to other biological components of human body, the skin is subjected to a complex and cumulative ageing process throughout life, which occurs due to structural and physiological changes caused by factors that are intrinsic and extrinsic to the body [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

148

102

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Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

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“…We also found that Wnt5a induced but Wnt5a knockdown suppressed TGFβ1 expression in HPDLCs. We recently reported that endogenous TGFβ1 contributed to the preservation of COL‐1 and FBN‐1 gene expression in PDL stem cells (Fujii et al, ), and others have shown that TGFβ1 increases the expression of periostin mRNA in human PDL fibroblasts (Wen et al, ) and human dermal fibroblasts (Egbert et al, ). In addition, periostin was reported to regulate collagen fibrillogenesis, thus maintaining proper collagen fibril formation and maturation in heart valves, skin, and tendon (Norris et al, ; Kudo, ).…”

Section: Discussionmentioning

confidence: 97%

Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1‐Mediated Upregulation of Periostin Expression

Hasegawa

Wada

Maeda

et al. 2015

Journal Cellular Physiology

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Wnt5a, a member of the noncanonical Wnt proteins, is known to play important roles in the development of various organs and in postnatal cell functions. However, little is known about the effects of Wnt5a on human periodontal ligament (PDL) cells. In this study, we examined the localization and potential function of Wnt5a in PDL tissue. Immunohistochemical analysis revealed that Wnt5a was expressed predominantly in rat PDL tissue. Semi-quantitative reverse-transcription polymerase chain reaction and Western blotting analysis demonstrated that human PDL cells (HPDLCs) expressed Wnt5a and its receptors (Ror2, Fzd2, Fzd4, and Fzd5). Removal of occlusal pressure by extraction of opposing teeth decreased Wnt5a expression in rat PDL tissue, and the expression of Wnt5a and its receptors in HPDLCs was upregulated by exposure to mechanical stress. Stimulation with Wnt5a significantly enhanced the proliferation and migration of HPDLCs. Furthermore, Wnt5a suppressed osteoblastic differentiation of HPDLCs cultivated in osteogenic induction medium, while it significantly enhanced the expression of PDL-related genes, such as periostin, type-I collagen, and fibrillin-1 genes, and the production of collagen in HPDLCs cultivated in normal medium. Both knockdown of periostin gene expression by siRNA and inhibition of TGFβ1 function by neutralizing antibody suppressed the Wnt5a-induced PDL-related gene expression and collagen production in HPDLCs. Interestingly, in HPDLCs cultured with Wnt5a, TGFβ1 neutralizing antibody significantly suppressed periostin expression, while periostin siRNA had no effect on TGFβ1 expression. These results suggest that Wnt5a expressed in PDL tissue plays specific roles in inducing collagen production by PDL cells through TGFβ1-mediated upregulation of periostin expression.

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The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging

Cited by 69 publications

References 44 publications

Anti-Wrinkle Effect of Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-kB Signaling

Anti-Wrinkle Effect of Magnesium Lithospermate B from Salvia miltiorrhiza BUNGE: Inhibition of MMPs via NF-kB Signaling

Elastin structure and its involvement in skin photoageing

Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1‐Mediated Upregulation of Periostin Expression

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