The Mean Platelet Volume in Patients with Retinal Vein Occlusion

Şahin, Alparslan; Şahin, Muhammed; Yüksel, Harun; Türkçü, Fatih Mehmet; Çınar, Yasin; Cingü, Abdullah Kürşat; Arı, Şeyhmus; Çaça, İhsan

doi:10.1155/2013/236371

Cited by 34 publications

(42 citation statements)

References 23 publications

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“…MPV has been studied in a few ocular vascular disorders. Our team reported an increase in MPV in patients with retinal vein occlusion (RVO) and ocular Behçet's disease (30,31) . Ateş et al found a significant increase in MPV in patients with diabetic retinopathy (32) .…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume in patients with retinal artery occlusion

Şahin¹,

Şahin²,

Yüksel³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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RESUMO Objetivo: O objetivo deste estudo foi investigar o volume plaquetário médio (MPV) de pacientes com oclusão da artéria da retina (RAO ABSTRACTPurpose: The aim of this study was to investigate the mean platelet volume (MPV) of patients with retinal artery occlusion (RAO). Methods: Thirty-seven patients diagnosed with RAO and 32 control subjects were included in this retrospective study. Retinal artery occlusion was diagnosed on the basis of clinical examination and fundus fluorescein angiography. All participants underwent complete ocular examination, and MPV, hematocrit, hemoglobin, and platelet counts were recorded. RAO patient data were compared with those of the control subjects.Results: Patients with RAO had significantly higher MPV values (7.96 ± 1.2 fL) com pared with control subjects (7.33 ± 0.7 fL, p<0.001). No significant difference was found with regard to platelet count between the RAO group and the control group (262 ± 70.1 × 10 9 /L and 251 ± 56.6 × 10 9 /L, respectively, p=0.50). MPV was an independent predictor of RAO [odds ratio (OR)=0.50; 95% confidence interval (CI)=0.28-0.89; p=0.019). Conclusions: Our results demonstrated that MPV values were significantly higher in patients with RAO, suggesting that larger platelets may contribute to the pathogenesis of the RAOs.

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Section: Discussionmentioning

confidence: 99%

Mean platelet volume in patients with retinal artery occlusion

Şahin¹,

Şahin²,

Yüksel³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…Also it has been studied that MPV is elevated in occlusion diseases and hence MPV can be used as predictive tool for identifying risk for retinal vein occlusion patients. Higher level of mean platelet volume is risk factor for patients with occlusions is been presented [13]. Macular edema is cause of vision disturbance.…”

Section: International Journal Of Computer Applications (0975 -8887)mentioning

confidence: 97%

Detection of Branch Retinal Vein Occlusion using Fractal Analysis

Zode¹,

Choudhari²

2017

IJCA

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“…Platelets play an important role in the pathogenesis of various thrombo-occlusive diseases, such as anterior ischemic optic neuropathy [6], ischemic and hemorrhagic stroke [7], and RVO [8]. Mean platelet volume (MPV) is a major indicator of the production rate and size of platelets, and has been associated with the activities of platelets [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Cao

Sun

2016

PLoS ONE

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PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.

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The Mean Platelet Volume in Patients with Retinal Vein Occlusion

Cited by 34 publications

References 23 publications

Mean platelet volume in patients with retinal artery occlusion

Mean platelet volume in patients with retinal artery occlusion

Detection of Branch Retinal Vein Occlusion using Fractal Analysis

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

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