The mechanical properties of porcine aortic valve tissues

Sauren, A.A.H.J.; Hout, M.C. van; Steenhoven, A.A. van; Veldpaus, F.E.; Janssen, JD Jan

doi:10.1016/0021-9290(83)90016-7

Cited by 122 publications

(58 citation statements)

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“…different means by other investigators. [35][36][37][38] The percent relaxation, and G-function parameters C and t 2 , measured in PAV leaflets in uniaxial tension were similar to values reported for PAV leaflets by Sauren et al 36 and Rousseau et al…”

Section: Discussionsupporting

confidence: 71%

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Planar Biaxial Behavior of Fibrin-Based Tissue-Engineered Heart Valve Leaflets

Robinson

Tranquillo

2009

Tissue Engineering Part A

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To design more effective tissue-engineered heart valve replacements, the replacement tissue may need to mimic the biaxial stress-strain behavior of native heart valve tissue. This study characterized the planar biaxial properties of tissue-engineered valve leaflets and native aortic valve leaflets. Fibrin-based valve equivalent (VE) and porcine aortic valve (PAV) leaflets were subjected to incremental biaxial stress relaxation testing, during which fiber alignments were measured, over a range of strain ratios. Results showed that VE leaflets exhibited a modulus and fiber reorientation behavior that correlated with strain ratio. In contrast, PAV leaflets maintained their relaxed modulus and fiber alignment when exposed to nonequibiaxial strain, but exhibited changes in stress relaxation. In uniaxial and equi-biaxial tension, there were few observed differences in relaxation behavior between VE and PAV leaflets, despite differences in the modulus and fiber reorientation. Likewise, in both tissues there was similar relaxation response in the circumferential and radial directions in biaxial tension, despite different moduli in these two directions. This study presents some fundamental differences in the mechanical response to biaxial tension of fibrin-based tissue-engineered constructs and native valve tissue. It also highlights the importance of using a range of strain ratios when generating mechanical property data for valvular and engineered tissues. The data presented on the stress-strain, relaxation, and fiber reorientation of VE tissue will be useful in future efforts to mathematically model and improve fibrin-based tissue-engineered constructs.

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Section: Discussionsupporting

confidence: 71%

“…PAV leaflets were used as a homolog to human aortic leaflets owing to their mechanical similarity [36][37][38] and use in current on the market heart valve replacements. While leaflets from the statically incubated VEs used in these studies had about an eightfold lower modulus than the PAV leaflets (Fig.…”

Section: Robinson and Tranquillomentioning

confidence: 99%

Planar Biaxial Behavior of Fibrin-Based Tissue-Engineered Heart Valve Leaflets

Robinson

Tranquillo

2009

Tissue Engineering Part A

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“…Like for many other soft tissues, initial measurements of valve leaflet tissue were measured by Instron-type uniaxial tester (Clark 1973;Missirlis and Chong 1978;Thubrikar et al 1980;Rousseau et al 1983;Sauren et al 1983;Vesely and Noseworthy 1992;Vesely and Lozon 1993). Valve tissue, even compared to other biological tissues, is particularly nonlinear, nonhomogeneous, and anisotropic.…”

Section: Tissue-scalementioning

confidence: 99%

On the multiscale modeling of heart valve biomechanics in health and disease

Weinberg

Shahmirzadi

Mofrad

2010

Biomech Model Mechanobiol

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Theoretical models of the human heart valves are useful tools for understanding and characterizing the dynamics of healthy and diseased valves. Enabled by advances in numerical modeling and in a range of disciplines within experimental biomechanics, recent models of the heart valves have become increasingly comprehensive and accurate. In this paper, we first review the fundamentals of native heart valve physiology, composition and mechanics in health and disease. We will then furnish an overview of the development of theoretical and experimental methods in modeling heart valve biomechanics over the past three decades. Next, we will emphasize the necessity of using multiscale modeling approaches in order to provide a comprehensive description of heart valve biomechanics able to capture general heart valve behavior. Finally, we will offer an outlook for the future of valve multiscale modeling, the potential directions for further developments and the challenges involved.

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“…(a) a typical uniaxial force-length relation for soft biological tissues; (b) uniaxial stress-strain relation for aorta-tissue from a sinus of Valsalva for different strain rates. From Sauren et al (1983).…”

Section: The Composition Of Biological Tissuesmentioning

confidence: 99%