The Mechanism of Action and Metabolism of Gonadotropic Hormones in the Organism

Zondek, Bernhard; Sulman, F. G.

doi:10.1016/s0083-6729(08)61115-2

Cited by 24 publications

(6 citation statements)

References 127 publications

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“…This phenomenon has been extensively used as an early test for human pregnancy by measuring the response in the rat ovary to HCG in pregnancy urine (Zondek & Sulman, 1945;Fried & Rakoff, 1950). The dramatic increase in blood flow through the transplanted sheep ovary which we observed with as little as 0-1 /tg.…”

Section: Discussionmentioning

confidence: 70%

The in-Vivo Effects of Sheep Pituitary Gonadotrophins on the Secretion of Steroids by the Autotransplanted Ovary of the Ewe

McCracken¹,

A²,

Goding³

et al. 1969

Journal of Endocrinology

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The transplanted ovary preparation in the ewe permits long-term access to both the arterial and venous sides of the ovarian circulation in the unstressed, unanaesthetized animal. However, these animals are not completely normal, as the separation of the ovary from the uterus results in ovarian cycles with a prolonged luteal phase and the infrequent manifestation of behavioural oestrus. Treatment with exogenous gonadotrophins made it possible to carry out direct infusion experiments on the transplanted ovary on a more uniform basis. The effect on ovarian blood flow and on ovarian steroid secretion following the infusion of ovine luteinizing hormone (LH), ovine follicle-stimulating hormone (FSH) or ovine prolactin directly into the arterial supply of the transplanted ovary of the ewe is described. Four infusions of each of the three ovine pituitary gonadotrophins were made into the ovary at rates varying from 0\m=.\1 \g=m\g./hr. to 1000 \g=m\g./hr. LH infusions produced an increase in both ovarian blood flow and steroid secretion at all dosage levels employed. Androstenedione showed the greatest increase (600%) in secretion rate after LH, followed by testosterone (400%), oestradiol (more than 50%) and progesterone (less than 50%). Progesterone however showed the greatest increase in terms of mass of steroid secreted. There was no measurable change in the secretion of oestrone. Ovarian blood flow increased by at least 20 % (range 20-125 %) within 1 hr. of beginning the LH infusion. On the other hand FSH and prolactin infused at the same or at a higher rate than LH, had essentially no effect on ovarian blood flow or steroid secretion rate. In two out of four FSH infusions there appeared to be a transient fall in progesterone secretion rate. The infusion of 0-9% NaCl solution into the ovary as a control had no effect on blood flow or on steroid secretion.

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Section: Discussionmentioning

confidence: 70%

The in-Vivo Effects of Sheep Pituitary Gonadotrophins on the Secretion of Steroids by the Autotransplanted Ovary of the Ewe

McCracken¹,

A²,

Goding³

et al. 1969

Journal of Endocrinology

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“…Moreover, the work of Everett [1947] shows that a much larger dose, 2 µg, of oestradiol is required to cause de¬ monstrable release of gonadotrophin from the pituitary of the rat during early pregnancy, and evidence of such release was not obtained until 24 hr had elapsed. Zondek & Sulman [1945] have described a similar time lag between the injection of gonadotrophin and the secretion of oestrogen. Neither of these two time sequences fit the above findings.…”

Section: Observationsmentioning

confidence: 81%

Endocrine Studies on Delayed Implantation in Lactating Mice

Wk¹

1958

Journal of Endocrinology

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When mouse ova were grafted under the renal capsule, the proportion of mice showing evidence of implantation was the same for normal and hypophysectomized animals.The injection of oestradiol dipropionate into pregnant lactating mice, on the 5th day post partum, produced macroscopic evidence of uterine implantation 26 hr later. This was not seen until 28 hr after an injection of serum gonadotrophin.The physiological significance of these findings is discussed.

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“…Both substances caused no effect on the expulsion of spermatozoa in Amphibia. b) Ovarian hyperemia in rats [8] Both substances had no chorionic gonadotrophic-like action.…”

Section: Tlc Investigation Of the Prepared Substancesmentioning

confidence: 98%

A Phytochemical Study of Date Palm Pollen

Mahran¹,

Abdelwahab²,

Attia³

1976

Planta Med

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investigation of Date Palm pollen revealed the presence of sterols, triterpenes, saponins, proteins, carbohydrates andlor glycosides and absence of volatile substances. From the U.S.M., B-amyrin, 8-sitosterol and a third crystalline substance were isolated. Four flavonoids were detected by TLC; two.of them were identified as rutin and quercetin. A steroidal saponin glycoside was isolated, having glucose and rhamnose as sugar moiety. A glucoprotein was isolated and proved biologically to have a gonadotrophic activity. TLC analysisprovedpresence of oesterone: Introdtrction Date Palm (Phoenix dactylifera L.; Palmae) is widely growing in Egypt and the pollen grains have been held for generations to be nutritive and therapeutic as an antisterility agent. ABOU EL-WAFA [I] reported the presence of a non-crystalline oestrogenic substance in the ether extract of-Date pollen; besides rutin, a saponin-like substance and sucrose. EL-RIDI [2] isolated, in a crude state, a gonadotrophicallyactive substance from the pollen, which was found to be toxic when injected into rats. B E N E~E [3] isolated oesterone and cholesterol from Date Palm pollen in U.S.A. FODA [4] reported the presence of a growth hormone in the alcohol extract of Date Palm pollen. In view of the significance of pollen grains a t the present time, we decided to reinvestigate its constituents applying some recent methods of identification, isolation and analysis. Materials The air-dried pollen grains of Date palm were collected during March and April 1972, 1973 and 1974 from Date palms growing in the Delta region of Egypt, mainly from Sharkia Province and immediately used after collection.

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The Mechanism of Action and Metabolism of Gonadotropic Hormones in the Organism

Cited by 24 publications

References 127 publications

The in-Vivo Effects of Sheep Pituitary Gonadotrophins on the Secretion of Steroids by the Autotransplanted Ovary of the Ewe

The in-Vivo Effects of Sheep Pituitary Gonadotrophins on the Secretion of Steroids by the Autotransplanted Ovary of the Ewe

Endocrine Studies on Delayed Implantation in Lactating Mice

A Phytochemical Study of Date Palm Pollen

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