The Mechanisms of HBV-Induced Hepatocellular Carcinoma

Yu, Jian; Han, Qiuju; Zhao, Huajun; Zhang, Jian

doi:10.2147/jhc.s307962

Cited by 136 publications

(92 citation statements)

References 148 publications

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“…Mutations of the viral genome causing biological behavior changes may have crucial effects on HBV pathogenicity and are closely associated with the malignant transition of liver cancer ( 21 ). The occurrence of HBV-associated HCC is a complex process.…”

Section: Epidemiologymentioning

confidence: 99%

Advances in Multi-Omics Applications in HBV-Associated Hepatocellular Carcinoma

Cui

et al. 2021

Front. Med.

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Hepatitis B virus (HBV) specifically infects liver cells, leading to progressive liver cirrhosis and significantly increasing the risk of hepatocellular carcinoma (HCC). The maturity of sequencing technology, improvement in bioinformatics data analysis and progress of omics technologies had improved research efficiency. The occurrence and progression of HCC are affected by multisystem and multilevel pathological changes. With the application of single-omics technologies, including genomics, transcriptomics, metabolomics and proteomics in tissue and body fluid samples, and even the novel development of multi-omics analysis on a single-cell platform, HBV-associated HCC changes can be better analyzed. The review summarizes the application of single omics and combined analysis of multi-omics data in HBV-associated HCC and proposes the importance of multi-omics analysis in the type of HCC, which provide the possibility for the precise diagnosis and therapy of HBV-associated HCC.

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Section: Epidemiologymentioning

confidence: 99%

Advances in Multi-Omics Applications in HBV-Associated Hepatocellular Carcinoma

Cui

et al. 2021

Front. Med.

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“…Upon loss of this balance, abnormally regulated genes promote aberrant signal transmission in the cell, in turn triggering dysregulation of metabolism, uncontrolled growth, immune imbalance, inflammation, and other malignant tumor-like changes that lead to the development of tumors over time. Various mechanisms, including epigenetics, exosomes, autophagy, metabolic regulation, and immune suppression, are under investigation in association with HCC, resulting in the gradual functional characterization of several uncontrolled genes [5].…”

Section: Pathological Characteristics and Clinical Development Of Hccmentioning

confidence: 99%

Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer

Huang

Liao

Huang

et al. 2021

Cancers

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Liver cancer is the leading cause of cancer-related mortality in the world. This mainly reflects the lack of early diagnosis tools and effective treatment methods. MicroRNAs (miRNAs) are a class of non-transcribed RNAs, some of which play important regulatory roles in liver cancer. Here, we discuss microRNAs with key impacts on liver cancer, such as miR-122, miR-21, miR-214, and miR-199. These microRNAs participate in various physiological regulatory pathways of liver cancer cells, and their modulation can have non-negligible effects in the treatment of liver cancer. We discuss whether these microRNAs can be used for better clinical diagnosis and/or drug development. With the advent of novel technologies, fast, inexpensive, and non-invasive RNA-based biomarker research has become a new mainstream approach. However, the clinical application of microRNA-based markers has been limited by the high sequence similarity among them and the potential for off-target problems. Therefore, researchers particularly value microRNAs that are specific to or have special functions in liver cancer. These include miR-122, which is specifically expressed in the liver, and miR-34, which is necessary for the replication of the hepatitis C virus in liver cancer. Clinical treatment drugs have been developed based on miR-34 and miR-122 (MRX34 and Miravirsen, respectively), but their side effects have not yet been overcome. Future research is needed to address these weaknesses and establish a feasible microRNA-based treatment strategy for liver cancer.

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“…HBV-induced hepatocarcinogenesis is a multistep process associated with changes in host gene expression, some of which have transforming and oncogenic potential. The HBV regulatory X protein (HBx) has been demonstrated to be involved in numerous mechanisms of oncogenesis by its interaction with a variety of host proteins [158].…”

Section: Regulation Of Mta1 Expression In Hbv-hccmentioning

confidence: 99%

Molecular Mechanisms and Animal Models of HBV-Related Hepatocellular Carcinoma: With Emphasis on Metastatic Tumor Antigen 1

Liu

2021

IJMS

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Hepatocellular carcinoma (HCC) is an important cause of cancer death worldwide, and hepatitis B virus (HBV) infection is a major etiology, particularly in the Asia-Pacific region. Lack of sensitive biomarkers for early diagnosis of HCC and lack of effective therapeutics for patients with advanced HCC are the main reasons for high HCC mortality; these clinical needs are linked to the molecular heterogeneity of hepatocarcinogenesis. Animal models are the basis of preclinical and translational research in HBV-related HCC (HBV-HCC). Recent advances in methodology have allowed the development of several animal models to address various aspects of chronic liver disease, including HCC, which HBV causes in humans. Currently, multiple HBV-HCC animal models, including conventional, hydrodynamics-transfection-based, viral vector-mediated transgenic, and xenograft mice models, as well as the hepadnavirus-infected tree shrew and woodchuck models, are available. This review provides an overview of molecular mechanisms and animal models of HBV-HCC. Additionally, the metastatic tumor antigen 1 (MTA1), a cancer-promoting molecule, was introduced as an example to address the importance of a suitable animal model for studying HBV-related hepatocarcinogenesis.

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The Mechanisms of HBV-Induced Hepatocellular Carcinoma

Cited by 136 publications

References 148 publications

Advances in Multi-Omics Applications in HBV-Associated Hepatocellular Carcinoma

Advances in Multi-Omics Applications in HBV-Associated Hepatocellular Carcinoma

Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer

Molecular Mechanisms and Animal Models of HBV-Related Hepatocellular Carcinoma: With Emphasis on Metastatic Tumor Antigen 1

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