The study was conducted to determine the differences of the research variables according to general characteristics of clinical nurses and to understand the factors affecting the job satisfaction of clinical nurses in Korea. Subjects were 330 clinical nurses. The results are as shown below; job stress and burnout were different according to age groups, level of education, work units, current positions, and clinical careers. For mindfulness, differences were found according to age groups, level of education, and current positions. For job satisfaction, differences were found according to age groups, level of education, work unit, current positions There was positive influence between job satisfaction and mindfulness, but both job stress and burnout were negative influences. The findings of this study implied that mindfulness had a positive impact, but job stress and burnout had a negative impact, on job satisfaction.