“…Plus, with the spread of the COVID-19 pandemic, the likelihood of suffering from MDD has increased significantly in different occupational groups ( Lokman and Bockting, 2022 ; Steen et al, 2022 ), such as COVID-19 survivors ( Mazza et al, 2022 ), healthcare workers ( Aoun et al, 2021 ; Moro et al, 2022 ), and self-quarantined people ( Nantaayi et al, 2022 ) around the world. Besides, MDD occurs not only as a primary disease alone, but also merges with other underlying diseases, including perimenopause ( Rudzinskas et al, 2021 ), puerperium ( Zeng et al, 2022 ), stroke ( Zhou et al, 2022 ), diabetes ( Bakker et al, 2022 ), Parkinson’s disease ( Xie et al, 2022 ), epilepsy ( Aimaier et al, 2022 ), hepatitis ( Gupta et al, 2020 ), gastritis ( Eustis et al, 2022 ), and brain cancer ( Nazli and Sevindik, 2022 ), as well as promotes the pathological development of the above diseases in turn. Thus, its occult pathogenesis features can easily lead to misdiagnosis ( Kostaras et al, 2017 ).…”