The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

Marks, Dustin H.; Penzi, Lauren R.; Ibler, Erin; Manatis-Lornell, Athena; Hagigeorges, Dina; Yasuda, Mariko; Drake, Lynn A.; Senna, Maryanne M.

doi:10.1007/s40257-018-0405-2

Cited by 50 publications

(49 citation statements)

References 54 publications

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“…Hair loss is a common dermatologic disorder that can be secondary to many causes. It is a stressful event that can be devastating to a patient's self‐esteem, self‐image, and overall quality of life …”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti‐hair loss lotion and shampoo) containing anti‐inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single‐arm, open‐label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. They used the combination of shampoo and lotion daily for 90 days. There was nonoccurrence of adverse events. Phototricogram showed increase in the average number of anagen hairs at T90 (P < .001). Scalp microphotography showed increase in total follicular units, total of hairs, and median hair per follicle unit at T90. There was an increase in diameter (P = .003) and in median maximum load and resistance to traction in T90 (P = .040). Combing and washing test demonstrated a decrease in the number of shed hairs before washing (P = .005), after washing (P = .01) and in total (P < .001). The use of shampoo+ lotion daily was safe and effective to attenuate hair loss in men and women with TE and/or AGA.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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show abstract

“…One explanation for this disparity could be the misdiagnosis or underdiagnosis of AA and its associated comorbidities in lower socioeconomic status patients because of the current paradigm that hair loss is purely a cosmetic illness. 23 Furthermore, hair often represents an essential element of femininity, fertility, and female attractiveness in society and may possibly have more profound psychosocial implications among wealthier societies in Asia. 23 Overall, skin cancer burden is relatively low in Asia.…”

Section: Discussionmentioning

confidence: 99%

“…23 Furthermore, hair often represents an essential element of femininity, fertility, and female attractiveness in society and may possibly have more profound psychosocial implications among wealthier societies in Asia. 23 Overall, skin cancer burden is relatively low in Asia. The incidence of cutaneous melanoma varies by ethnicity, with white populations having a substantially higher incidence rate (21.9 to 55.9 per 100,000) than Asian populations (0.2 to 0.5 per 100,000).…”

Section: Discussionmentioning

confidence: 99%

Burden of skin disease and associated socioeconomic status in Asia: A cross-sectional analysis from the Global Burden of Disease Study 1990-2017

et al. 2021

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Introduction Skin diseases have a significant global impact on quality of life, mental health, and loss of income. The burden of dermatologic conditions and its relationship with socioeconomic status in Asia is currently not well understood. Methods We selected Global Burden of Disease Study datasets to analyze disability-adjusted life years (DALYs) in 50 Asian countries, including Central Asia, northern Asia, eastern Asia, western Asia, southeastern Asia, and southern Asia, between 1990 and 2017. We compared DALYs to the socioeconomic status using the sociodemographic index and gross domestic product per capita of a country. Statistical analysis was performed using Pearson's correlation. Results Some countries had higher or lower than expected age-standardized DALY rates of skin diseases. Asian countries, especially high-income countries, had a high burden of inflammatory dermatoses, including acne, alopecia areata, atopic dermatitis, contact dermatitis, decubitus ulcers, psoriasis, pruritus, and seborrheic dermatitis. The burden of infectious dermatoses was greater in low-income Asian countries. The burden of skin cancer in Asia was relatively low. Conclusion There is a high burden of skin disease, especially inflammatory conditions, in Asian countries, but the burden of individual dermatoses in Asia varies by country and socioeconomic status. DALYs can potentially serve as a purposeful measure for directing resources to improve the burden of skin disease in Asia.

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“…Hair loss (alopecia) is a disease that affects a growing number of people worldwide and impacts individuals' physical, psychological, and social well‐being . Patients with hair disorders suffer from emotional stress, embarrassment, and depression that severely compromise their life quality .…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

Castro

Logarinho

2019

Stem Cells Translational Medicine

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The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation into hair follicle replacement therapies has not occurred. Great expectation has been recently put on hair follicle bioengineering, which is based on the development of fully functional hair follicles with cycling activity from an expanded population of hair‐inductive (trichogenic) cells. Most bioengineering approaches focus on in vitro reconstruction of folliculogenesis by manipulating key regulatory molecular/physical features of hair follicle growth/cycling in vivo. Despite their great potential, no cell‐based product is clinically available for hair regeneration therapy to date. This is mainly due to demanding issues that still hinder the functionality of cultured human hair cells. The present review comprehensively compares emergent strategies using different cell sources and tissue engineering approaches, aiming to successfully achieve a clinical cure for hair loss. The hurdles of these strategies are discussed, as well as the future directions to overcome the obstacles and fulfill the promise of a “hairy” feat.

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The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

Cited by 50 publications

References 54 publications

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Burden of skin disease and associated socioeconomic status in Asia: A cross-sectional analysis from the Global Burden of Disease Study 1990-2017

Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

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