The Microbiome in Pancreatic Cancer-Implications for Diagnosis and Precision Bacteriophage Therapy for This Low Survival Disease

Kabwe, Mwila; Dashper, Stuart; Tucci, Joseph

doi:10.3389/fcimb.2022.871293

Cited by 10 publications

(7 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…as well as Michaud et al [5,10]. Similarly Kabwe et al summarized latest literature regarding possible use of oral microbiomes as cancer markers, and found that it might be arduous to single out a specific bacteria universally linked to PC risks [18]. They also pointed out that comparing studies with different methodology is crucial to distinguish the connection of oral microbiome and PC, other than results drafted from oral wash samples only.…”

Section: Resultsmentioning

confidence: 99%

Microbial alterations of oral cavity and their association with Pancreatic Cancer

Radziejowska

Bielak²,

Gryta³

et al. 2023

View full text Add to dashboard Cite

Introduction: Pancreatic Cancer (PC), while relatively infrequent, remains one of the deadliest cancers as a result of late diagnosis and absence of preventive measures. Over 50 % of patients diagnosed with PC already suffer metastasis. Combined with lack of effective treatment, the need arises for universal biomarkers specific to PC. In the last decades the importance of human microbiota in its upholding of the body homeostasis has been under radar, in special regards to its association to cancer. Several species of oral microbiome have been linked to increased or decreased risk of developing pancreatic cancer, most notably P.gingivalis and Fusobacteria. Purpose of the study: The aim of this study is to collect and summarize existing evidence on connection of oral microbiome and pancreatic cancer, as well as to assess their potential use in diagnostics of PC . Material and method: Literature review was performed, in English databases, using keywords : cancer, pancreatic cancer, pancreatic cancer prevention, oral microbiome, microbe variation, microbial biomarkers. Results and conclusions: In our systematic review, evident differences between microbial architecture of PC patients and healthy individuals were observed. The data on association between microbiota and risk of developing cancer is limited, however it still provides evidence for relationship between microbial composition and incidence of pancreatic cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Microbial alterations of oral cavity and their association with Pancreatic Cancer

Radziejowska

Bielak²,

Gryta³

et al. 2023

View full text Add to dashboard Cite

show abstract

“…tested the vancomycin resistance in Veillonella strains from oral of healthy adults by agar dilution method ( Li et al., 2022 ). In the fecal samples, Prevotella , Streptococcus , and Klebsiella were the differential abundant microbes in the pancreatic cancer cohort compared with healthy cohort ( Kabwe et al., 2022 ). The genus Streptococcus has been studied for its association with cancer progression and treatment outcomes over an extended period ( Sobocki et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Gut resistome profiling reveals high diversity and fluctuations in pancreatic cancer cohorts

Liu,

Li,

Yang

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundPancreatic cancer is one of the deadliest cancer, with a 5-year overall survival rate of 11%. Unfortunately, most patients are diagnosed with advanced stage by the time they present with symptoms. In the past decade, microbiome studies have explored the association of pancreatic cancer with the human oral and gut microbiomes. However, the gut microbial antibiotic resistance genes profiling of pancreatic cancer patients was never reported compared to that of the healthy cohort.ResultsIn this study, we addressed the gut microbial antibiotic resistance genes profile using the metagenomic data from two online public pancreatic cancer cohorts. We found a high degree of data concordance between the two cohorts, which can therefore be used for cross-sectional comparisons. Meanwhile, we used two strategies to predict antibiotic resistance genes and compared the advantages and disadvantages of these two approaches. We also constructed microbe-antibiotic resistance gene networks and found that most of the hub nodes in the networks were antibiotic resistance genes.ConclusionsIn summary, we describe the panorama of antibiotic resistance genes in the gut microbes of patients with pancreatic cancer. We hope that our study will provide new perspectives on treatment options for the disease.

show abstract

“…Therefore, its use as an anti-tumor strategy should be carefully considered. Considering this, bacteriophage therapy is emerging as an alternative to precisely target specific bacteria associated with progression and poor prognosis in cancer, 30 , 142 , 143 but it has not been formally explored in PDAC yet.…”

Section: Microbiota Modulation Has Therapeutic Potential In Pdacmentioning

confidence: 99%

Roles of microbiota in pancreatic cancer development and treatment

Cruz,

Tintelnot,

Gagliani

2024

Gut Microbes

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced and palliative disease stage, and there is a high incidence of therapy resistance. Despite ongoing efforts, to date, the mechanisms underlying PDAC oncogenesis and its poor responses to treatment are still largely unclear. As the study of the microbiome in cancer progresses, growing evidence suggests that bacteria or fungi might be key players both in PDAC oncogenesis as well as in its resistance to chemo- and immunotherapy, for instance through modulation of the tumor microenvironment and reshaping of the host immune response. Here, we review how the microbiota exerts these effects directly or indirectly via microbial-derived metabolites. Finally, we further discuss the potential of modulating the microbiota composition as a therapy in PDAC.

show abstract

The Microbiome in Pancreatic Cancer-Implications for Diagnosis and Precision Bacteriophage Therapy for This Low Survival Disease

Cited by 10 publications

References 167 publications

Microbial alterations of oral cavity and their association with Pancreatic Cancer

Microbial alterations of oral cavity and their association with Pancreatic Cancer

Gut resistome profiling reveals high diversity and fluctuations in pancreatic cancer cohorts

Roles of microbiota in pancreatic cancer development and treatment

Contact Info

Product

Resources

About