The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23

Abstract

Our study shows that miR-367 is a key negative regulator of the invasion and metastasis of gastric cancer and establishes a strong rationale for developing miR-367 as a novel therapeutic agent against gastric cancer.

Research Article miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN.

“…However, in contrast to these oncogenic characteristics, miR-367 is downregulated in gastric cancer (Bin et al, 2015), glioma (Guan et al, 2015), and cervical carcinoma (Cai et al, 2013). Reduced miR-367 expression in gastric cancer tissues correlates with tumor metastasis and advanced tumor-node-metastasis stage (Bin et al, 2015), and its overexpression has been shown to inhibit gastric cancer cell invasion via direct suppression of Rab23 (Bin et al, 2015). Ectopic expression of miR-367 restricts proliferation and blocks the G1/S transition of cervical cancer cells through regulation of AKT1 (Cai et al, 2013), and low miR-367 level is an independent indicator of unfavorable prognosis for glioma patients (Guan et al, 2015).…”

“…In addition, this miRNA suppresses Adriamycininduced apoptosis of osteosarcoma cells by targeting KLF4 (Wang et al, 2016). However, in contrast to these oncogenic characteristics, miR-367 is downregulated in gastric cancer (Bin et al, 2015), glioma (Guan et al, 2015), and cervical carcinoma (Cai et al, 2013). Reduced miR-367 expression in gastric cancer tissues correlates with tumor metastasis and advanced tumor-node-metastasis stage (Bin et al, 2015), and its overexpression has been shown to inhibit gastric cancer cell invasion via direct suppression of Rab23 (Bin et al, 2015).…”

“…miR-367 has recently been identified as a novel tumor-related miRNA in colon cancer (Chae et al, 2013), breast cancer (Zhang et al, 2011), medulloblastoma (Kaid et al, 2015), esophageal squamous cell carcinoma (ESCC; Sun et al, 2016), gastric cancer (Bin et al, 2015), osteosarcoma (Wang et al, 2016), hepatocellular carcinoma (Meng et al, 2016), glioma (Guan et al, 2015), pancreatic ductal adenocarcinoma (Zhu et al, 2015), non-small cell lung cancer (NSCLC; Campayo et al, 2013), and cervical carcinoma (Cai et al, 2013). Modulation of miR-367 expression can affect several aspects of cancer cell behavior, including proliferation, apoptosis, invasion, and epithelial-to-mesenchymal transition.…”

The Role of mir-152 and DNMT1 in Gastric Cancer Cell Proliferation and Invasion

“…More than 60% of human protein-coding genes contain at least one conserved miRNA -binding site, and considering that numerous non-conserved sites also exist, most protein-coding genes may be under the control of miRNAs [9]. A lot of study suggested that miRNA plays crucial roles in many biological processes such as development, inflammation, differentiation, cell proliferation, apoptosis and invasion [10][11][12][13]. Thus, their dysregulation is often associated with human diseases, including cancer and neurodevelopmental disorders [14,15].…”

miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC

“…Recent studies revealed that miR-367 participates in the tumorigenesis of various types of cancers, such as hepatocellular carcinoma (5), medulloblastoma (6) and pancreatic cancer (7). In contrast, in the study of gastric carcinoma, miR-367 inhibited cell migration and invasion, and its expression in cancer tissues was much lower than that in normal stomach tissues (8). This implied that miR-367 may play different roles in various tumors.…”