The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

“…In the case of the downregulated miRNAs from the MIR17HG family (miR‐17, miR‐18a, miR‐19a, miR‐19b1, miR‐20a and, miR‐92a), some of them have been found to be downregulated in several cellular aging models (Hackl et al, 2010). Consistent with our findings, miR‐17 has been reported to inhibit senescence in mouse cardiac fibroblasts (Du et al, 2015) and miR‐19a and miR‐19b to indirectly inhibit autophagy and apoptosis in human cardiac fibroblasts. We found MIR155‐HG as upregulated.…”

Effects of miRNAs on myocardial apoptosis by modulating mitochondria related proteins

“…Several miRNAs perform a variety of roles in cardiovascular diseases by modulating expression of other mitochondrial function proteins or factors under various pressures (Figure ). MiR‐7a/b, miR‐17, miR‐17‐92 cluster, miR‐21, miR‐24, and miR‐101 play anti‐apoptotic roles in cardiac myocytes under H/R or MI by directly targeting apoptotic machineries. For instance, miR‐17 targets Apaf‐1, caspase‐3/7 and ‐8 activity is attenuated by miR‐125b, miR‐7a/b blocks apoptosis executor poly (ADP‐ribose) polymerase (PARP) expression, and AKT related survival signalling activity is downregulated by miR‐17‐92 cluster and miR‐21 .…”

The Biological Functions of Non-coding RNAs: From a Line to a Circle

“…Other than their roles in cancer, miRNAs are also involved in a variety of human diseases and biological processes. Our recent work shows that miRNAs, including miR-17 and miR-378 are important to wound healing, senescence as well as lipid metabolism (114)(115)(116)(117). We've also found that miR-17 controls the organ development.…”