The microstructure and component distribution in spray-dried emulsion particles

Munoz-Ibanez, Marta; Nuzzo, Marine; Turchiuli, Christelle; Bergenståhl, Björn; Dumoulin, Élisabeth; Millqvist‐Fureby, Anna

doi:10.1016/j.foostr.2016.05.001

Cited by 41 publications

(15 citation statements)

References 30 publications

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“…However, this perception changed over the years driven by the increasing demand for particles with engineered end-use properties, that is to say particles with improved properties like dissolution rate, controlled release, flowability, wettability, compactibility and coating [2,3]. Therefore, spray drying has become nowadays a tool for designing solid structures, specially from multi-component feeds.…”

Section: Introductionmentioning

confidence: 99%

Changing spray-dried lactose-whey protein isolate particle structure with drying conditions

Lima

Gutierez

Arlabosse

et al. 2018

Proceedings of 21th International Drying Symposium

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Spray drying has become not merely a drying process, but also an important tool for engineering solid structures, specially for multi-component feeds. In that way, it is important to know how the drying conditions and liquid formulations affect the particle final solid structure. In the present study, we investigated the changes on the solid structure of a spray-dried binary mixture of lactose and whey protein isolate under different process and formulation conditions. Particle morphology, diameter, porosity and occluded air were analyzed. Total solid content in the feed was the parameter of highest impact on the spray-dried particle’s occluded air volume.Keywords: spray drying; solid structure; porosity; hollow particless.

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Section: Introductionmentioning

confidence: 99%

Changing spray-dried lactose-whey protein isolate particle structure with drying conditions

Lima

Gutierez

Arlabosse

et al. 2018

Proceedings of 21th International Drying Symposium

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show abstract

“…A small droplet size distribution of emulsions prior to spray drying has shown to be a main impact factor for EE with smaller droplets leading to a higher EE [31]. In SD emulsions which are stabilized by additional emulsifiers, GA has shown to be of no advantage concerning EE and oxidation stability compared to MD [32].…”

Section: Resultsmentioning

confidence: 99%

Stabilization of Crystalline Carotenoids in Carrot Concentrate Powders: Effects of Drying Technology, Carrier Material, and Antioxidants

Haas

Robben²,

Kiesslich³

et al. 2019

Foods

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Coloring concentrates of carotenoid-rich plant materials are currently used in the food industry to meet the consumer’s demand for natural substitutes for food colorants. The production of shelf-stable powders of such concentrates comes with particular challenges linked to the sensitivity of the active component towards oxidation and the complexity of the composition and microstructure of such concentrates. In this study, different strategies for the stabilization of crystalline carotenoids as part of a natural carrot concentrate matrix during drying and storage were investigated. The evaluated approaches included spray- and freeze drying, the addition of functional additives, and oxygen free storage. Functional additives comprised carrier material (maltodextrin, gum Arabic, and octenyl succinic anhydride (OSA)-modified starch) and antioxidants (mixed tocopherols, sodium ascorbate). Degradation and changes in the physical state of the carotenoid crystals were monitored during processing and storage. Carotenoid losses during processing were low (>5%) irrespective of the used technology and additives. During storage, samples stored in nitrogen showed the highest carotenoid retention (97–100%). The carotenoid retention in powders stored with air access varied between 12.3% ± 2.1% and 66.0% ± 5.4%, having been affected by the particle structure as well as the formulation components used. The comparative evaluation of the tested strategies allows a more targeted design of processing and formulation of functional carrot concentrate powders.

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“…Spray drying is a common method for preparing dry emulsions [ 8 , 9 ]. Starch [ 10 ], lactose [ 11 ], maltodextrin [ 12 ], mannitol [ 13 ], dextran [ 14 ] and hydroxypropyl methylcellulose [ 15 ] are commonly solid carriers used in spray drying of emulsions. The solid carrier may have important impact on the properties of spray-dried emulsions.…”

Section: Introductionmentioning

confidence: 99%

A Novel Solid Nanocrystals Self-Stabilized Pickering Emulsion Prepared by Spray-Drying with Hydroxypropyl-β-cyclodextrin as Carriers

Zhang

Wang

et al. 2021

Molecules

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A drug nanocrystals self-stabilized Pickering emulsion (NSSPE) with a unique composition and microstructure has been proven to significantly increase the bioavailability of poorly soluble drugs. This study aimed to develop a new solid NSSPE of puerarin preserving the original microstructure of NSSPE by spray-drying. A series of water-soluble solid carriers were compared and then Box-Behnken design was used to optimize the parameters of spray-drying. The drug release and stability of the optimized solid NSSPE in vitro were also investigated. The results showed that hydroxypropyl-β-cyclodextrin (HP-β-CD), rather than solid carriers commonly used in solidification of traditional Pickering emulsions, was suitable for the solid NSSPE to retain the original appearance and size of emulsion droplets after reconstitution. The amount of HP-β-CD had more influences on the solid NSSPE than the feed rate and the inlet air temperature. Fluorescence microscopy, confocal laser scanning microscopy and scanning electron microscopy showed that the reconstituted emulsion of the solid NSSPE prepared with HP-β-CD had the same core-shell structure with a core of oil and a shell of puerarin nanocrystals as the liquid NSSPE. The particle size of puerarin nanocrystal sand interfacial adsorption rate also did not change significantly. The cumulative amount of released puerarin from the solid NSSPE had no significant difference compared with the liquid NSSPE, which were both significantly higher than that of puerarin crude material. The solid NSSPE was stable for 3 months under the accelerated condition of 75% relative humidity and 40 °C. Thus, it is possible todevelop the solid NSSPE preserving the unique microstructure and the superior properties in vitro of the liquid NSSPE for poorly soluble drugs.

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The microstructure and component distribution in spray-dried emulsion particles

Cited by 41 publications

References 30 publications

Changing spray-dried lactose-whey protein isolate particle structure with drying conditions

Changing spray-dried lactose-whey protein isolate particle structure with drying conditions

Stabilization of Crystalline Carotenoids in Carrot Concentrate Powders: Effects of Drying Technology, Carrier Material, and Antioxidants

A Novel Solid Nanocrystals Self-Stabilized Pickering Emulsion Prepared by Spray-Drying with Hydroxypropyl-β-cyclodextrin as Carriers

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